We have compared the prognostic value of MDR1 RNA expression with that of other clinical
parameters in 63 patients with acute myeloid leukemia. MDR1 RNA expression of the …

To prospectively assess the role of MDR1 gene expression in patients with de novo acute
myeloid leukemia (AML), levels of MDR1 RNA in blast cells were determined at diagnosis …

Acute myeloid leukemia (AML) has a poor long-term prognosis, with a disease-free survival
rate of only 20%. Drug resistance remains the major obstacle in this disease, although …

In an attempt to determine the incidence and clinical relevance of mdr1 gene expression in
acute myeloid leukemia (AML), we examined 126 specimens obtained from adult patients …

This is a comment on" Multidrug resistance (MDR 1) in leukemia: is it time to test?" Blood.
1992 Jan 15; 79 (2): 295-8. This is a comment on" Clinical significance of multidrug …

In order to confirm our initial report on the negative impact of MDR1 gene expression on the
outcome of de novo acute myeloid leukemia (AML), we present an update of our prospective …

By using a quantitative RNA-RNA solution hybridisation method, the average number of
mdr1 RNA transcripts per cell was measured in total nucleic acid extracts of leukaemic cells …

The MDR1 gene is of prognostic significance in acute myeloid leukemia (AML). The
relationship of this gene to surface markers largely remains unclear. Therefore, we have …

Resistance to multiple chemotherapeutic agents is related to the production of P-
glycoprotein, a transmembrane drug efflux pump that is encoded by the multidrug resistance …

The Multidrug Resistance gene (MDR 1) is frequently expressed in acute myeloid leukaemia
(AML). MDR 1 is associated with resistance to chemotherapy in vitro and with a poor …