Topological alterations in human spermatozoa associated with the polyelectrolytic effect of RISUG®

S Kumar, K Chaudhury, P Sen, SK Guha - Micron, 2006 - Elsevier
A new method of male contraception has been developed which results in long-term
infertility and has the potential advantage of being reversible. The contraceptive, given the …

Quantitative analysis of surface micro‐roughness alterations in human spermatozoa using atomic force microscopy

S Kumar, K Chaudhury, P Sen… - Journal of microscopy, 2007 - Wiley Online Library
A new male contraceptive given the name RISUG®(an acronym for Reversible Inhibition of
Sperm Under Guidance) has been developed by our research group. RISUG® is a bioactive …

Study of the micro‐structural properties of RISUG®—A newly developed male contraceptive

S Kumar, S Roy, K Chaudhury, P Sen… - Journal of Biomedical …, 2008 - Wiley Online Library
A new male contraceptive given the name RISUG®(an acronym for reversible inhibition of
sperm under guidance) and presently undergoing advanced clinical trials has been …

Biophysical mechanism‐mediated time‐dependent effect on sperm of human and monkey vas implanted polyelectrolyte contraceptive

SK Guha - Asian journal of andrology, 2007 - Wiley Online Library
Aim: To determine the short and long‐term morphological effects on sperm as induced by
intra‐vas alteration of pH and electrical charge. Methods: Desired biophysical influences …

Studies on the membrane integrity of human sperm treated with a new injectable male contraceptive

K Chaudhury, AK Bhattacharyya… - Human …, 2004 - academic.oup.com
BACKGROUND: The aim of this study was to evaluate the integrity of sperm surface
characteristics in the presence of a new male contraceptive, RISUG [1 mg styrene maleic …

Spermicidal action of styrene maleic anhydride polyelectrolyte in combination with magnetic and electrically conductive particles

RK Jha, PK Jha, SV Rana, SK Guha - Int J Pharmacol, 2009 - hero.epa.gov
The aim of this study is to evaluate impact of a new polymeric contraceptive SMA-Fe (3) O
(4)-Cu-DMSO called Smart RISUG (acronym for Smart Reversible Inhibition of Sperm under …

Functional attenuation of human sperm by novel, non-surfactant spermicides: precise targeting of membrane physiology without affecting structure

RK Jain, A Jain, R Kumar, V Verma… - Human …, 2010 - academic.oup.com
BACKGROUND We have attempted to identify structural, physiological and other targets on
human sperm vulnerable to the spermicidal action of two novel series of non-detergent …

RISUG: A new perspective in non–hormonal male contraception

V Thakur, M Choudhary, V Mehta, D Kumar - Asian Pacific Journal of …, 2013 - Elsevier
Currently there are several hormonal and non-hormonal methods of contraception available
but due to long term side effects of hormonal contraceptives, a great research is undergoing …

Capacitation of ram spermatozoa promotes changes in energy metabolism and aquaporin 3 and is affected by individual testosterone variations

P Peris‐Frau, A Sanchez‐Rodriguez, R Velázquez… - …, 2024 - Wiley Online Library
Background Recently, the metabolic pathways involved in energy production and the role of
aquaglyceroporins in capacitation‐associated events have been studied in humans and …

RISUG™(reversible inhibition of sperm under guidance)–an antimicrobial as male vas deferens implant for HIV free semen

SK Guha - Medical hypotheses, 2005 - Elsevier
HIV transmission from the male to the female is a major health problem. A hypothesis
proposing an intra vas deferens implant of an antimicrobial compound to prevent the …