Action potential energy efficiency varies among neuron types in vertebrates and invertebrates
The initiation and propagation of action potentials (APs) places high demands on the
energetic resources of neural tissue. Each AP forces ATP-driven ion pumps to work harder …
energetic resources of neural tissue. Each AP forces ATP-driven ion pumps to work harder …
Metabolic energy cost of action potential velocity
P Crotty, T Sangrey, WB Levy - Journal of Neurophysiology, 2006 - journals.physiology.org
The action potential of the unmyelinated nerve is metabolically expensive. Using the
energetic cost per unit length for the biophysically modeled action potential of the squid …
energetic cost per unit length for the biophysically modeled action potential of the squid …
Warm body temperature facilitates energy efficient cortical action potentials
Y Yu, AP Hill, DA McCormick - PLoS computational biology, 2012 - journals.plos.org
The energy efficiency of neural signal transmission is important not only as a limiting factor
in brain architecture, but it also influences the interpretation of functional brain imaging …
in brain architecture, but it also influences the interpretation of functional brain imaging …
State and location dependence of action potential metabolic cost in cortical pyramidal neurons
Action potential generation and conduction requires large quantities of energy to restore
Na+ and K+ ion gradients. We investigated the subcellular location and voltage dependence …
Na+ and K+ ion gradients. We investigated the subcellular location and voltage dependence …
Membrane potential and action potential
DA McCormick - From molecules to networks, 2014 - Elsevier
It is now known that action potential generation in nearly all types of neurons and muscle
cells is accomplished through mechanisms similar to those first detailed in the squid giant …
cells is accomplished through mechanisms similar to those first detailed in the squid giant …
Metabolic cost as a unifying principle governing neuronal biophysics
A Hasenstaub, S Otte, E Callaway… - Proceedings of the …, 2010 - National Acad Sciences
The brain contains an astonishing diversity of neurons, each expressing only one set of ion
channels out of the billions of potential channel combinations. Simple organizing principles …
channels out of the billions of potential channel combinations. Simple organizing principles …
Excitability of the squid giant axon revisited
JR Clay - Journal of neurophysiology, 1998 - journals.physiology.org
Clay, John R. Excitability of the squid giant axon revisited. J. Neurophysiol. 80: 903–913,
1998. The electrical properties of the giant axon from the common squid Loligo pealei have …
1998. The electrical properties of the giant axon from the common squid Loligo pealei have …
Neuronal energy consumption: biophysics, efficiency and evolution
JE Niven - Current opinion in neurobiology, 2016 - Elsevier
Highlights•Electrical signaling consumes substantial amounts of energy influencing
physiology and anatomy.•Action potential energy consumption depends on the voltage …
physiology and anatomy.•Action potential energy consumption depends on the voltage …
Ionic channel function in action potential generation: current perspective
G Baranauskas - Molecular neurobiology, 2007 - Springer
Over 50 years ago, Hodgkin and Huxley laid down the foundations of our current
understanding of ionic channels. An impressive progress has been made during the …
understanding of ionic channels. An impressive progress has been made during the …
Theoretical relation between axon initial segment geometry and excitability
S Goethals, R Brette - Elife, 2020 - elifesciences.org
In most vertebrate neurons, action potentials are triggered at the distal end of the axon initial
segment (AIS). Both position and length of the AIS vary across and within neuron types, with …
segment (AIS). Both position and length of the AIS vary across and within neuron types, with …