Antimicrobial resistance represents a significant challenge to future healthcare provision. An
acronym ESKAPEE has been derived from the names of the organisms recognised as the …

Bacterial antibiotic resistance is rapidly becoming a major world health consideration. To
combat antibiotics, microorganisms employ their pre-existing defence mechanisms that …

Bacterial infections pose a serious public health concern, especially when an infectious
disease has a multidrug resistant causative agent. Such multidrug resistant bacteria can …

Multiple antibiotic resistance in bacteria was at first thought to be caused exclusively by the
combination of several resistance genes, each coding for resistance to a single drug. More …

Multidrug resistance (MDR) in Gram-negative pathogens, such as the Enterobacteriaceae
and Pseudomonas aeruginosa, poses a significant threat to our ability to effectively treat …

The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level.
The treatment options against infections caused by multiple drug-resistant bacteria are …

Many antibiotics inhibit gram-negative bacteria less effectively than gram-positive bacteria,
because the outer membrane permeability barrier allows only a slow influx of drugs, and the …

Chemoresistance presents a general health problem concerning the therapy of infectious
disease and cancer. In this context, the worldwide dissemination of “multidrugresistant” …

Antibiotic resistance is on the rise and has become one of the biggest public health
challenges of our time. Bacteria are able to adapt to the selective pressure exerted by …

Minimum inhibitory concentrations (MICs) of most lipophilic agents tend to be much higher
against gram-negative than gram-positive bacteria. Multidrug efflux pumps that traverse both …