Autoimmune diseases, rejection of transplanted organs and grafts, chronic inflammatory
diseases, and immune‐mediated rejection of biologic drugs impact a large number of …

Traditional bone replacement materials have been developed with the goal of directing the
osteogenesis of osteoblastic cell lines toward differentiation and therefore achieving …

The monocyte-derived macrophage is recognized as a critical determinant in
biocompatibility, but its appearance in the chronic inflammatory phase is accompanied by …

The material-induced foreign body response is a major challenge for implanted medical
devices. This review highlights recent developments in biomimetic approaches to create …

Background: Treatment of large bone defects represents a major clinical problem worldwide.
Suitable bone substitute materials are commonly required to achieve successful bone …

The immune system plays an indispensable role in the process of tissue regeneration
following damage as well as during homeostasis. Inflammation and immune cell recruitment …

Immune cells have emerged as powerful regulators of regenerative as well as pathological
processes. The vast majority of regenerative immunoengineering efforts have focused on …

During hematoma formation following injury, an inflammatory reaction ensues as an initial
step in the healing process. As granulation tissue matures, revascularization is a …

Biomedical devices comprise a major component of modern medicine, however immune-
mediated fibrosis and rejection can limit their function over time. Here, we describe a …

The optimal treatment for complex fractures and large bone defects is an important unsolved
issue in orthopedics and related specialties. Approximately 5–10% of fractures fail to heal …