Control of innate immune response by biomaterial surface topography, energy, and stiffness
JO Abaricia, N Farzad, TJ Heath, J Simmons… - Acta Biomaterialia, 2021 - Elsevier
As the focus of implantable biomaterials has shifted from bioinert implants to bioactive
designs, recent research has highlighted the complex interactions between cell physiologic …
designs, recent research has highlighted the complex interactions between cell physiologic …
Inflammation and bone repair: from particle disease to tissue regeneration
SB Goodman, J Pajarinen, Z Yao, T Lin - Frontiers in Bioengineering …, 2019 - frontiersin.org
When presented with an adverse stimulus, organisms evoke an immediate, pre-
programmed, non-specific innate immune response. The purpose of this reaction is to …
programmed, non-specific innate immune response. The purpose of this reaction is to …
Modulation of the inflammatory response and bone healing
M Maruyama, C Rhee, T Utsunomiya… - Frontiers in …, 2020 - frontiersin.org
The optimal treatment for complex fractures and large bone defects is an important unsolved
issue in orthopedics and related specialties. Approximately 5–10% of fractures fail to heal …
issue in orthopedics and related specialties. Approximately 5–10% of fractures fail to heal …
Tailoring biomaterials for cancer immunotherapy: emerging trends and future outlook
Cancer immunotherapy, as a paradigm shift in cancer treatment, has recently received
tremendous attention. The active cancer vaccination, immune checkpoint blockage (ICB) …
tremendous attention. The active cancer vaccination, immune checkpoint blockage (ICB) …
[HTML][HTML] Extracellular matrix scaffold-immune microenvironment modulates tissue regeneration
Y Yu, W Zhang, X Liu, H Wang, J Shen, H Xiao… - Composites Part B …, 2022 - Elsevier
A promising paradigm to regenerative medicine involves the application of biomaterials,
which makes a spurt of progress in the past 20 years. Of various biomaterials, decellularized …
which makes a spurt of progress in the past 20 years. Of various biomaterials, decellularized …
Harnessing innate immunity using biomaterials for cancer immunotherapy
The discovery of immune checkpoint blockade has revolutionized the field of immuno‐
oncology and established the foundation for developing various new therapies that can …
oncology and established the foundation for developing various new therapies that can …
Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury
Successful tissue repair requires the activities of myeloid cells such as monocytes and
macrophages that guide the progression of inflammation and healing outcome …
macrophages that guide the progression of inflammation and healing outcome …
The scaffold immune microenvironment: biomaterial-mediated immune polarization in traumatic and nontraumatic applications
The immune system mediates tissue growth and homeostasis and is the first responder to
injury or biomaterial implantation. Recently, it has been appreciated that immune cells play a …
injury or biomaterial implantation. Recently, it has been appreciated that immune cells play a …
Harnessing and modulating inflammation in strategies for bone regeneration
PM Mountziaris, PP Spicer, FK Kasper… - … Engineering Part B …, 2011 - liebertpub.com
Inflammation is an immediate response that plays a critical role in healing after fracture or
injury to bone. However, in certain clinical contexts, such as in inflammatory diseases or in …
injury to bone. However, in certain clinical contexts, such as in inflammatory diseases or in …
Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds
In normal tissue repair, macrophages exhibit a pro-inflammatory phenotype (M1) at early
stages and a pro-healing phenotype (M2) at later stages. We have previously shown that M1 …
stages and a pro-healing phenotype (M2) at later stages. We have previously shown that M1 …