The Inhibitory Effect of 3β‐Hydroxy‐12‐oleanen‐27‐oic Acid on Growth and Motility of Human Hepatoma HepG2 Cells through JNK and Akt Signaling Pathway

J Wang, X Chen, Z Zhou, J Li… - … and Alternative Medicine, 2013 - Wiley Online Library
3β‐Hydroxy‐12‐oleanen‐27‐oic acid (ATA) was a main antitumor active triterpene from the
rhizomes of Astilbe chinensis. In this study, we investigated its effects on growth, apoptosis …

3β-Hydroxy-12-oleanen-27-oic Acid Exerts an Antiproliferative Effect on Human Colon Carcinoma HCT116 Cells via Targeting FDFT1

J Tu, X Meng, J Wang, Z Han, Z Yu, H Sun - International Journal of …, 2023 - mdpi.com
3 β-hydroxy-12-oleanen-27-oic acid (ATA), a cytotoxic oleanane triterpenoid with C14-
COOH isolated from the rhizome of Astilbe chinensis, has been previously proven to …

Induction of apoptosis in HeLa cells by 3β-hydroxy-12-oleanen-27-oic acid from the rhizomes of Astilbe chinensis

HX Sun, QF Zheng, J Tu - Bioorganic & medicinal chemistry, 2006 - Elsevier
3β-Hydroxy-12-oleanen-27-oic acid (ATA) was an antitumor active oleanane-type
triterpenoid from the rhizomes of Astilbe chinensis. ATA was structurally very similar to …

Three new 3-formyl-2-arylbenzofurans from Itea yunnanensis and their anti-hepatocellular carcinoma effects

TQ Lang, GY Luo, WC Pu, ZW Wang… - Natural Product …, 2022 - Taylor & Francis
Abstract Five 3-formyl-2-arylbenzofuran derivatives, including three new compounds (1-3)
and two known analogues (4-5), were identified from the 95% EtOH extract of Itea …

Immunomodulatory Activity of 3β,6β‐Dihydroxyolean‐12‐en‐27‐oic Acid in Tumor‐Bearing Mice

W Deng, HX Sun, FY Chen, ML Yao - Chemistry & Biodiversity, 2009 - Wiley Online Library
Abstract 3β, 6β‐Dihydroxyolean‐12‐en‐27‐oic acid (1) is a pentacyclic triterpenoid isolated
from the rhizomes of Astilbe chinensis. To evaluate the in vivo antitumor potential and to …

Trilobolide‐6‐O‐isobutyrate suppresses hepatocellular carcinoma tumorigenesis through inhibition of IL‐6/STAT3 signaling pathway

XQ Zhou, XM Mao, R Fan, SY Li, J Shang… - Phytotherapy …, 2021 - Wiley Online Library
Currently available therapies for hepatocellular carcinoma (HCC), with a high morbidity and
high mortality, are only marginally effective and with sharp adverse side effects, which …

Apoptosis and G2/M cell cycle arrest induced by a timosaponin A3 from Anemarrhena asphodeloides Bunge on AsPC-1 pancreatic cancer cells

Y Kim, KH Kim, IS Lee, JY Park, YC Na, WS Chung… - Phytomedicine, 2019 - Elsevier
Abstract Background Timosaponin A3 (TA3), one of the active components of spirostanol
saponin isolated from A. asphodeloides, is widely used as an anticancer agent in a variety of …

Cytotoxic and anti-tumor effects of 3,4-seco-lupane triterpenoids from the leaves of Eleutherococcus sessiliflorus against hepatocellular carcinoma

H Wang, W Yu, D Zhang, Y Zhao, C Chen… - Natural Product …, 2022 - Taylor & Francis
Abstract A rich of 3, 4-seco-lupane triterpenoids (3, 4-SLT), including chiisanoside (CSS),
divaroside (DVS), sessiloside-A1 (SSA), chiisanogenin (CSG), sessiligenin (SSG), were …

[HTML][HTML] 22β-hydroxytingenone induces apoptosis and suppresses invasiveness of melanoma cells by inhibiting MMP-9 activity and MAPK signaling

ESP Aranha, AJ de Sousa Portilho, LB de Sousa… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance 22β-hydroxytingenone (22-HTG) is a
quinonemethide triterpene isolated from Salacia impressifolia (Miers) AC Smith (family …

The effects of Alisol B 23-acetate in hepatocellular carcinoma via inducing cell apoptosis and inhibiting cell migration and invasion.

L Li, J Cheng, D Zhu, X Shi, Y Wei… - General Physiology …, 2020 - search.ebscohost.com
Abstract Alisol B 23-acetate (AB23A) is a natural triterpenoid isolated from Chinese herbal
medicine and has a variety of biological functions, especially anti-cancer effects. However …