eIF4A3 is a novel component of the exon junction complex
The exon junction complex (EJC) is a protein complex that assembles near exon–exon
junctions of mRNAs as a result of splicing. EJC proteins play important roles in postsplicing …
junctions of mRNAs as a result of splicing. EJC proteins play important roles in postsplicing …
eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay
T Shibuya, TØ Tange, N Sonenberg… - Nature structural & …, 2004 - nature.com
The exon junction complex (EJC), a set of proteins deposited on mRNAs as a consequence
of pre-mRNA splicing, is a key effector of downstream mRNA metabolism. We have …
of pre-mRNA splicing, is a key effector of downstream mRNA metabolism. We have …
The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity
L Ballut, B Marchadier, A Baguet, C Tomasetto… - Nature structural & …, 2005 - nature.com
The multiprotein exon junction complex (EJC) is assembled on mRNAs as a consequence of
splicing. EJC core components maintain a stable grip on mRNAs even as the overall EJC …
splicing. EJC core components maintain a stable grip on mRNAs even as the overall EJC …
Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly
I Barbosa, N Haque, F Fiorini, C Barrandon… - Nature structural & …, 2012 - nature.com
The exon-junction complex (EJC) functionally links splicing to subsequent mRNA
localization, translation and stability. Sequence-independent binding of the EJC core to RNA …
localization, translation and stability. Sequence-independent binding of the EJC core to RNA …
Structure of the Y14-Magoh core of the exon junction complex
CK Lau, MD Diem, G Dreyfuss, GD Van Duyne - Current Biology, 2003 - cell.com
Background: Splicing of pre-mRNA in eukaryotes imprints the resulting mRNA with a specific
multiprotein complex, the exon-exon junction complex (EJC), at the sites of intron removal …
multiprotein complex, the exon-exon junction complex (EJC), at the sites of intron removal …
[HTML][HTML] Translation is required to remove Y14 from mRNAs in the cytoplasm
J Dostie, G Dreyfuss - Current Biology, 2002 - cell.com
Background: Y14 is an RNA binding protein which is part of a multiprotein complex, the exon-
exon junction complex (EJC), that assembles on the exon-exon junctions of mRNAs …
exon junction complex (EJC), that assembles on the exon-exon junctions of mRNAs …
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core
The multiprotein exon junction complex (EJC) is deposited on mRNAs upstream of exon–
exon junctions as a consequence of pre-mRNA splicing. In mammalian cells, this complex …
exon junctions as a consequence of pre-mRNA splicing. In mammalian cells, this complex …
Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and-independent recruitment of exon junction complex components
Z Zhang, AR Krainer - … of the National Academy of Sciences, 2007 - National Acad Sciences
Pre-mRNA splicing not only removes introns and joins exons to generate spliced mRNA but
also results in remodeling of the spliced messenger ribonucleoprotein, influencing various …
also results in remodeling of the spliced messenger ribonucleoprotein, influencing various …
Transcriptome-wide modulation of splicing by the exon junction complex
Z Wang, V Murigneux, H Le Hir - Genome biology, 2014 - Springer
Background The exon junction complex (EJC) is a dynamic multi-protein complex deposited
onto nuclear spliced mRNAs upstream of exon-exon junctions. The four core proteins …
onto nuclear spliced mRNAs upstream of exon-exon junctions. The four core proteins …
[HTML][HTML] The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA
F Bono, J Ebert, E Lorentzen, E Conti - Cell, 2006 - cell.com
The exon junction complex (EJC) plays a major role in posttranscriptional regulation of
mRNA in metazoa. The EJC is deposited onto mRNA during splicing and is transported to …
mRNA in metazoa. The EJC is deposited onto mRNA during splicing and is transported to …