Sarcopenia and Cognitive decline in older adults: targeting the muscle–brain Axis

B Arosio, R Calvani, E Ferri, HJ Coelho-Junior… - Nutrients, 2023 - mdpi.com
Declines in physical performance and cognition are commonly observed in older adults. The
geroscience paradigm posits that a set of processes and pathways shared among age …

Muscle–Brain crosstalk in cognitive impairment

X Han, M Ashraf, SM Tipparaju, W Xuan - Frontiers in Aging …, 2023 - frontiersin.org
Sarcopenia is an age-related, involuntary loss of skeletal muscle mass and strength.
Alzheimer's disease (AD) is the most common cause of dementia in elderly adults. To date …

Sarcopenia and cognitive function: role of myokines in muscle brain cross-talk

L Scisciola, RA Fontanella, Surina, V Cataldo… - Life, 2021 - mdpi.com
Sarcopenia is a geriatric syndrome characterized by the progressive degeneration of muscle
mass and function, and it is associated with severe complications, which are falls, functional …

Pathophysiological mechanisms explaining the association between low skeletal muscle mass and cognitive function

SJ Oudbier, J Goh, SMLM Looijaard… - The Journals of …, 2022 - academic.oup.com
Low skeletal muscle mass is associated with cognitive impairment and dementia in older
adults. This review describes the possible underlying pathophysiological mechanisms …

Sarcopenia and neuroscience: learning to communicate

BC Clark, RG Carson - The Journals of Gerontology: Series A, 2021 - academic.oup.com
In the 1990s and early 2000s, the common definition for sarcopenia was age-related loss of
skeletal muscle, and low levels of muscle mass were central to sarcopenia diagnosis. In …

Sarcopenia and the common mental disorders: a potential regulatory role of skeletal muscle on brain function?

JA Pasco, LJ Williams, FN Jacka, N Stupka… - Current osteoporosis …, 2015 - Springer
While it is understood that body composition impacts on physical conditions, such as
diabetes and cardiovascular disease, it is only now apparent that body composition might …

Sarcopenia: aging-related loss of muscle mass and function

L Larsson, H Degens, M Li, L Salviati… - Physiological …, 2019 - journals.physiology.org
Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

Searching for a mitochondrial root to the decline in muscle function with ageing

M Gonzalez‐Freire, F Adelnia… - Journal of cachexia …, 2018 - Wiley Online Library
Sarcopenia, the age‐related loss of muscle mass and strength, is linked to a range of
adverse outcomes, such as impaired physical performance, cognitive function, and mortality …

Skeletal muscle health and cognitive function: a narrative review

SX Sui, LJ Williams, KL Holloway-Kew… - International journal of …, 2020 - mdpi.com
Sarcopenia is the loss of skeletal muscle mass and function with advancing age. It involves
both complex genetic and modifiable risk factors, such as lack of exercise, malnutrition and …

Neural mechanisms of age-related loss of muscle performance and physical function

BC Clark - The Journals of Gerontology: Series A, 2023 - academic.oup.com
Background: This article discusses the putative neural mechanisms of age-related muscle
weakness within the broader context of the development of function-promoting therapies for …