In the management of a patient with severe sepsis, it is important to suspect the infection
early, to collect samples immediately after diagnosis and to promptly initiate a broad …

The management of a patient with severe sepsis is first to diagnose the infection, to collect
samples immediately after diagnosis and to initiate promptly broad-spectrum antibiotic …

Sepsis is becoming more common in hospital patients and, despite developments in
management, the morbidity and mortality of severe sepsis is still significant. Early …

Severe sepsis and septic shock remain the leading causes of multiple organ failure and
mortality in surgical intensive care units. Early antibiotic therapy recently became a …

Appropriate antibiotic therapy in patients with severe sepsis and septic shock should mean
prompt achievement and maintenance of optimal exposure at the infection site with broad …

Introduction: Severe infections in critically ill patients carry a high morbidity and mortality
rate. Given the impact of early and broad-spectrum empirical therapy in several studies and …

Severe infection and its evolution to sepsis are becoming more prevalent every day and are
among the leading causes of critical illness and mortality. Proper management is crucial to …

Sepsis is a medical emergency and life-threatening condition due to a dysregulated host
response to infection, with unacceptably high morbidity and mortality. Similar to acute …

Objectives: To assess the use of antibiotic de-escalation in patients with hospital-acquired
severe sepsis in an academic setting. Design: We reviewed all episodes of severe sepsis …

Abstract Severe infections (SIs) in Intensive Care Units (ICUs) constitute difficult therapeutic
problems confronting clinicians who deal with severely ill patients. Some SIs are …