Background The constant increase in development and spread of bacterial resistance to
antibiotics poses a serious threat to human health. New sequencing technologies are now …

Genomics offered the promise of transforming antibiotic discovery by revealing many new
essential genes as good targets, but the results fell short of the promise. While numerous …

Background Pseudomonas aeruginosa is an opportunistic pathogen with a high incidence
of hospital infections that represents a threat to immune compromised patients. Genomic …

Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF)
contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its …

In this chapter, we leverage a novel approach to assess the seamless population structure of
Pseudomonas aeruginosa, using the full repertoire of genomes sequenced to date …

Background Pseudomonas aeruginosa is an opportunistic pathogen consisting of three
phylogroups (hereafter named A, B, and C). Here, we assessed phylogroup-specific …

The essential functions of a bacterial pathogen reflect the most basic processes required for
its viability and growth, and represent potential therapeutic targets. Most screens for …

Up to 20% of the chromosomal Pseudomonas aeruginosa DNA belong to the so-called
accessory genome. Its elements are specific for subgroups or even single strains and are …

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen particularly
associated with the inherited disease cystic fibrosis (CF). Pseudomonas aeruginosa is well …

The first Pseudomonas genome was sequenced in 2000, and at 6.3 million base pairs, it
was, at the time, the largest bacterial genome ever sequenced (Stover et al., 2000). Not …