Our current understanding of the mechanisms of action of antitumor agents and the precise
mechanisms underlying drug resistance is that these two processes are directly linked …

Inhibitors of thymidylate synthase (TS) play an essential role in the pharmacological
management of several tumors. Two antifolates, Raltitrexed and Pemetrexed, are licensed …

Thymidylate synthase (TS) catalyses the de novo synthesis of deoxythymidylate and is a key
rate-limiting enzyme of DNA synthesis. The primary site of action of the classic antifolate …

Thymidylate synthase (TS) is a folate-dependent enzyme that catalyzes the reductive
methylation of 2′-deoxyuridine-5′-monophosphate to 2′-deoxythymidine-5 …

Thymidylate synthase (TS) is an essential enzyme in de novo synthesis of thymidylate, and
is required for DNA synthesis and cell proliferation in the absence of exogenous thymidine …

Understanding the relationship between chemical structure and biological properties of
folate analogs, particularly their Interactions with the target enzymes, transport proteins and …

Over the past 60 years, chemotherapeutic agents that target thymidylate biosynthesis and
the enzyme thymidylate synthase (TS) have remained among the most-successful drugs …

Recent methodologies applied to the drug discovery process, such as genomics and
proteomics, have greatly implemented our basic understanding of drug action and are giving …

Thymidylate synthase is an important target for both fluorinated pyrimidines and for new
folate analogues. Resistance to 5-fluorouracil (5FU) can be related to insufficient inhibition …

Tumor cell resistance to fluoropyrimidines and other inhibitors of thymidylate synthase (TS)
is a serious problem often associated with increased intracellular TS. Clinically, another …