Small-cell lung cancer

CM Rudin, E Brambilla, C Faivre-Finn… - Nature Reviews Disease …, 2021 - nature.com
Small-cell lung cancer (SCLC) represents about 15% of all lung cancers and is marked by
an exceptionally high proliferative rate, strong predilection for early metastasis and poor …

[HTML][HTML] Small cell lung cancer: can recent advances in biology and molecular biology be translated into improved outcomes?

PA Bunn Jr, JD Minna, A Augustyn, AF Gazdar… - Journal of Thoracic …, 2016 - Elsevier
Small cell lung cancer (SCLC) is one of the four major histological types of lung cancer. The
incidence of SCLC in developed countries has declined in recent years, presumably …

Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions

Z Megyesfalvi, CM Gay, H Popper… - CA: a cancer journal …, 2023 - Wiley Online Library
Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity.
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …

[HTML][HTML] Small cell lung cancer (SCLC): no treatment advances in recent years

F Koinis, A Kotsakis, V Georgoulias - Translational lung cancer …, 2016 - ncbi.nlm.nih.gov
Small cell lung cancer (SCLC) is an aggressive malignancy with a distinct natural history
and dismal prognosis. Given its predisposition for early dissemination, patients are …

Small-cell lung cancer: what we know, what we need to know and the path forward

AF Gazdar, PA Bunn, JD Minna - Nature Reviews Cancer, 2017 - nature.com
Small-cell lung cancer (SCLC) is a deadly tumour accounting for approximately 15% of lung
cancers and is pathologically, molecularly, biologically and clinically very different from other …

[HTML][HTML] Small cell lung cancer: a slightly less orphan disease after immunotherapy

J Remon, M Aldea, B Besse, D Planchard, M Reck… - Annals of …, 2021 - Elsevier
Highlights•ICIs have shifted the treatment paradigm to improve overall survival in advanced
SCLC.•The magnitude of immune-chemotherapy strategy is still modest. The …

Small cell lung cancer: where do we go from here?

LA Byers, CM Rudin - Cancer, 2015 - Wiley Online Library
Small cell lung cancer (SCLC) is an aggressive disease that accounts for approximately
14% of all lung cancers. In the United States, approximately 31,000 patients are diagnosed …

Update on the biology, management, and treatment of small cell lung cancer (SCLC)

A Saltos, M Shafique, A Chiappori - Frontiers in oncology, 2020 - frontiersin.org
Small-cell lung cancer (SCLC) accounts for 13–15% of all new lung cancer cases in the US.
The tumor has a tendency to disseminate early resulting in 80–85% of patients being …

[HTML][HTML] Cellular and molecular biology of small cell lung cancer: an overview

N Karachaliou, S Pilotto, C Lazzari, E Bria… - … lung cancer research, 2016 - ncbi.nlm.nih.gov
Although the incidence of small cell lung cancer (SCLC) has declined during the past 30
years, it remains a frustrating disease to research and treat. Numerous attempts to enhance …

Signal pathways and precision therapy of small-cell lung cancer

M Yuan, Y Zhao, HT Arkenau, T Lao, L Chu… - Signal transduction and …, 2022 - nature.com
Small-cell lung cancer (SCLC) encounters up 15% of all lung cancers, and is characterized
by a high rate of proliferation, a tendency for early metastasis and generally poor prognosis …