Jnk2 deletion disrupts intestinal mucosal homeostasis and maturation by differentially modulating RNA-binding proteins HuR and CUGBP1
HK Chung, JN Rao, T Zou, L Liu… - … of Physiology-Cell …, 2014 - journals.physiology.org
Homeostasis and maturation of the mammalian intestinal epithelium are preserved through
strict regulation of cell proliferation, apoptosis, and differentiation, but the exact mechanism …
strict regulation of cell proliferation, apoptosis, and differentiation, but the exact mechanism …
c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression
C Tong, Z Yin, Z Song, A Dockendorff, C Huang… - The American journal of …, 2007 - Elsevier
The c-Jun NH2-terminal kinase (JNK) signal transduction pathway plays important roles in
cellular processes and stress. However, the role of JNK1 in intestinal homeostasis and …
cellular processes and stress. However, the role of JNK1 in intestinal homeostasis and …
JNK signalling modulates intestinal homeostasis and tumourigenesis in mice
R Sancho, AS Nateri, AG De Vinuesa, C Aguilera… - The EMBO …, 2009 - embopress.org
Wnt signalling is a crucial signalling pathway controlling intestinal homeostasis and cancer.
We show here that the JNK MAP kinase pathway and one of its most important substrates …
We show here that the JNK MAP kinase pathway and one of its most important substrates …
[HTML][HTML] c-Jun N-terminal kinase 2 promotes enterocyte survival and goblet cell differentiation in the inflamed intestine
Abstract c-Jun N-terminal kinases (JNKs) contribute to immune signaling but their functional
role during intestinal mucosal inflammation has remained ill defined. Using genetic mouse …
role during intestinal mucosal inflammation has remained ill defined. Using genetic mouse …
RNA-binding protein HuR regulates Paneth cell function by altering membrane localization of TLR2 via post-transcriptional control of CNPY3
L Xiao, XX Li, HK Chung, S Kalakonda, JZ Cai, S Cao… - Gastroenterology, 2019 - Elsevier
Background & Aims Paneth cells secrete antimicrobial proteins including lysozyme via
secretory autophagy as part of the mucosal protective response. The ELAV like RNA-binding …
secretory autophagy as part of the mucosal protective response. The ELAV like RNA-binding …
RNA-binding protein HuR promotes growth of small intestinal mucosa by activating the Wnt signaling pathway
L Liu, E Christodoulou-Vafeiadou, JN Rao… - Molecular biology of …, 2014 - Am Soc Cell Biol
Inhibition of growth of the intestinal epithelium, a rapidly self-renewing tissue, is commonly
found in various critical disorders. The RNA-binding protein HuR is highly expressed in the …
found in various critical disorders. The RNA-binding protein HuR is highly expressed in the …
[HTML][HTML] RNA-binding protein HuR regulates Rac1 nucleocytoplasmic shuttling through nucleophosmin in the intestinal epithelium
L Liu, L Xiao, HK Chung, MS Kwon, XX Li, N Wu… - Cellular and Molecular …, 2019 - Elsevier
Background & Aims The mammalian intestinal epithelium is a rapidly self-renewing tissue in
the body, and its homeostasis is tightly regulated via well-controlled mechanisms. The RNA …
the body, and its homeostasis is tightly regulated via well-controlled mechanisms. The RNA …
Wdr5-mediated H3K4me3 coordinately regulates cell differentiation, proliferation termination, and survival in digestive organogenesis
Z Zhang, C Yang, Z Wang, L Guo, Y Xu, C Gao… - Cell Death …, 2023 - nature.com
Food digestion requires the cooperation of different digestive organs. The differentiation of
digestive organs is crucial for larvae to start feeding. Therefore, during digestive …
digestive organs is crucial for larvae to start feeding. Therefore, during digestive …
[HTML][HTML] Jwa participates the maintenance of intestinal epithelial homeostasis via ERK/FBXW7-mediated NOTCH1/PPARγ/STAT5 axis and acts as a novel putative …
X Li, J Liu, Y Zhou, L Wang, Y Wen, K Ding… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
The intestinal epithelium is a rapid self-renewal and regenerated tissue of which the
structural integrity is beneficial for maintaining health. The integrity of intestinal epithelium …
structural integrity is beneficial for maintaining health. The integrity of intestinal epithelium …
Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function
TX Yu, PY Wang, JN Rao, T Zou, L Liu… - Nucleic acids …, 2011 - academic.oup.com
Occludin is a transmembrane tight junction (TJ) protein that plays an important role in TJ
assembly and regulation of the epithelial barrier function, but the mechanisms underlying its …
assembly and regulation of the epithelial barrier function, but the mechanisms underlying its …