We recently reported that dysregulated c-Jun N-terminal kinases (JNK) activity causes
defective cell cycle checkpoint control, inducing neoplastic transformation in a cellular …

The integrity of the intestinal epithelium is crucial for the barrier function of the gut.
Replenishment of the gut epithelium by intestinal stem cells contributes to gut homeostasis …

During intestinal organogenesis, equipotent epithelial progenitors mature into
phenotypically distinct stem cells that are responsible for lifelong maintenance of the tissue …

Three distinct groups of mitogen-activated protein kinases (MAPKs) have been identified in
mammalian cells (ie, ERK, JNK, and p38) which play an important role in the differentiation …

RNA-binding proteins CUG-binding protein 1 (CUGBP1) and HuR are highly expressed in
epithelial tissues and modulate the stability and translation of target mRNAs. Here we …

Polycomb‐group proteins form multimeric protein complexes involved in transcriptional
silencing. The Polycomb Repressive complex 2 (PRC2) contains the Suppressor of Zeste …

We have previously shown that the sequential transcription factors Xbp1→ Mist1 (Bhlha15)
govern the ultrastructural maturation of the secretory apparatus in enzyme-secreting …

Metazoans employ cytoprotective and regenerative strategies to maintain tissue
homeostasis. Understanding the coordination of these strategies is critical to developing …

The RNA-binding protein HuR is crucial for normal intestinal mucosal regeneration by
modulating the stability and translation of target mRNAs, but the exact mechanism …

The c-Jun N-terminal kinases (JNKs) are considered as novel targets for therapy of
inflammatory bowel diseases (IBD). However, the relevant JNK isoforms have to be …