Gastrointestinal epithelium faces osmotic stress, both at physiological and
pathophysiological conditions. JNK activation is an immediate cellular response to osmotic …

Impaired epithelial regeneration is a crucial pathophysiological feature of ulcerative colitis
(UC). Yes-associated protein (YAP1) appears to control cell proliferation and differentiation …

The activation of the biliary stem‐cell signaling pathway hairy and enhancer of split
1/pancreatic duodenal homeobox‐1 (Hes‐1/PDX‐1) in mature cholangiocytes determines …

MEK-1 [MAPK (mitogen-activated protein kinase) kinase-1] is an important signal
transducing enzyme that is implicated in many aspects of cellular functions. In the present …

Abstract Analysis of knockout animals indicates that 3′, 5′ cyclic guanosine
monophosphate (cGMP) has an important role in gut homeostasis but the signaling …

Intestinal cell kinase (ICK), originally cloned from the intestine and expressed in the
intestinal crypt epithelium, is a highly conserved serine/threonine protein kinase that is …

HuR is a ubiquitous nucleocytoplasmic RNA-binding protein that exerts pleiotropic effects on
cell growth and tumorigenesis. In this study, we explored the impact of conditional, tissue …

NKX family members are involved in a variety of developmental processes such as cell fate
determination in the central nervous system, gastrointestinal tract, and pancreas. However …

Background & Aims p21-activated kinase-1 (PAK1) belongs to a family of serine-threonine
kinases and contributes to cellular pathways such as nuclear factor-κB (NF-κB), mitogen …

Background We have recently reported that mitogen-activated protein kinase (MAPK) JNK1
downregulates β-catenin signaling and plays a critical role in regulating intestinal …