High-mobility group A1 (Hmga1) chromatin remodelling proteins are enriched in intestinal
stem cells (ISCs), although their function in this setting was unknown. Prior studies showed …

Ribosome biogenesis is an essential cellular process. Its impairment is associated with
developmental defects and increased risk of cancer. The in vivo cellular responses to …

Gut barrier dysfunction occurs commonly in patients with critical disorders, leading to the
translocation of luminal toxic substances and bacteria to the bloodstream. Connexin 43 …

In normal intestines, a fetal/regenerative/revival cell state can be induced upon
inflammation. This plasticity in cell fate is also one of the current topics in human colorectal …

Intestinal epithelial tight junctions (TJs) are a specialized structure that determines the cell
polarity and prevents the diffusion of toxins, allergens, and pathogens from the lumen into …

Background Long non‐coding RNA KCNQ1 opposite strand/antisense transcript one gene
(KCNQ1OT1) has been reported to be involved in the progression of many types of human …

The cJun NH2-terminal kinase (JNK) signal transduction pathway has been implicated in the
growth of carcinogen-induced hepatocellular carcinoma. However, the mechanism that …

Abstract C-Jun-N-terminal-kinases (JNKs), members of the mitogen-activated-protein-kinase
family, are significantly linked with neurological and neurodegenerative pathologies and …

Specified intestinal epithelial cells reprogram and contribute to the regeneration and
renewal of the epithelium upon injury. Mutations that deregulate such renewal processes …

The mammalian intestinal epithelium is a rapidly self-renewing tissue in the body and its
homeostasis is tightly controlled by numerous factors at multiple levels. The RNA-binding …