Microorganisms have provided abundant sources of natural products which have been
developed as commercial products for human medicine, animal health, and plant crop …

The actinomycetes, including in particular members of the filamentous genus Streptomyces,
are the industrial source of a large number of bioactive small molecules employed as …

Actinomycetes are excellent sources for novel bioactive compounds, which serve as
potential drug candidates for antibiotics development. While industrial efforts to find and …

Bacteria harbor an immense reservoir of potentially new and therapeutic small molecules in
the form of “silent” biosynthetic gene clusters (BGCs). These BGCs can be identified …

Actinomycetes are well known as an inexhaustible source for antibiotics. Most of the known
antimicrobials today were originally isolated from actinomycetes, especially from the genus …

The need for new antimicrobials is indisputable. The flight from natural products in drug
discovery was unfortunate; however, the revolution that is genome mining, enabled by the …

Analyses of microbial genome sequences have revealed numerous examples of 'cryptic'or
'orphan'biosynthetic gene clusters, with the potential to direct the production of novel …

Actinobacteria are Gram-positive bacteria with high G+ C DNA content that constitute one of
the largest bacterial phyla, and they are ubiquitously distributed in both aquatic and …

The soil actinomycetes have been important sources of antibiotics, but were nearly
abandoned in recent years in favor of high-throughput target-based screening of chemical …

Actinomycetes, filamentous actinobacteria found in numerous ecosystems around the globe,
produce a wide range of clinically useful natural products (NP). In natural environments …