A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice
Autism spectrum disorders (ASDs) are characterized by impairments in social behaviors that
are sometimes coupled to specialized cognitive abilities. A small percentage of ASD patients …
are sometimes coupled to specialized cognitive abilities. A small percentage of ASD patients …
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function
Multiple independent mutations in neuroligin genes were identified in patients with familial
autism, including the R451C substitution in neuroligin-3 (NL3). Previous studies showed that …
autism, including the R451C substitution in neuroligin-3 (NL3). Previous studies showed that …
Autism‐related neuroligin‐3 mutation alters social behavior and spatial learning
TC Jaramillo, S Liu, A Pettersen, SG Birnbaum… - Autism …, 2014 - Wiley Online Library
Multiple candidate genes have been identified for autism spectrum disorders. While some of
these genes reach genome‐wide significance, others, such as the R451C point mutation in …
these genes reach genome‐wide significance, others, such as the R451C point mutation in …
Neuroligin-1–dependent competition regulates cortical synaptogenesis and synapse number
Members of the neuroligin family of cell-adhesion proteins are found at excitatory and
inhibitory synapses and are mutated in some familial forms of autism spectrum disorders …
inhibitory synapses and are mutated in some familial forms of autism spectrum disorders …
Shared synaptic pathophysiology in syndromic and nonsyndromic rodent models of autism
SJ Baudouin, J Gaudias, S Gerharz, L Hatstatt, K Zhou… - Science, 2012 - science.org
The genetic heterogeneity of autism poses a major challenge for identifying mechanism-
based treatments. A number of rare mutations are associated with autism, and it is unclear …
based treatments. A number of rare mutations are associated with autism, and it is unclear …
Autism's cause may reside in abnormalities at the synapse
K Garber - Science, 2007 - science.org
Published by AAAS account for about 1% of autism cases. Then, in March 2007, the Autism
Genome Project Consortium, a group of over 50 institutions in North America and Europe …
Genome Project Consortium, a group of over 50 institutions in North America and Europe …
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
Many studies have supported a genetic etiology for autism. Here we report mutations in two
X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum …
X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum …
Unique versus redundant functions of neuroligin genes in shaping excitatory and inhibitory synapse properties
Neuroligins are evolutionarily conserved postsynaptic cell adhesion molecules that interact
with presynaptic neurexins. Neurons express multiple neuroligin isoforms that are targeted …
with presynaptic neurexins. Neurons express multiple neuroligin isoforms that are targeted …
Increased anxiety‐like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2
J Blundell, K Tabuchi, MF Bolliger… - Genes, Brain and …, 2009 - Wiley Online Library
Neuroligins (NL) are postsynaptic cell adhesion molecules that are thought to specify
synapse properties. Previous studies showed that mutant mice carrying an autism …
synapse properties. Previous studies showed that mutant mice carrying an autism …
Minimal aberrant behavioral phenotypes of neuroligin‐3 R451C knockin mice
KK Chadman, S Gong, ML Scattoni… - Autism …, 2008 - Wiley Online Library
Neuroligin‐3 is a member of the class of cell adhesion proteins that mediate synapse
development and have been implicated in autism. Mice with the human R451C mutation …
development and have been implicated in autism. Mice with the human R451C mutation …