Neuroligins and neurexins link synaptic function to cognitive disease

TC Südhof - Nature, 2008 - nature.com
The brain processes information by transmitting signals at synapses, which connect neurons
into vast networks of communicating cells. In these networks, synapses not only transmit …

Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions

X Chen, H Liu, AHR Shim, PJ Focia, X He - Nature structural & …, 2008 - nature.com
The heterophilic synaptic adhesion molecules neuroligins and neurexins are essential for
establishing and maintaining neuronal circuits by modulating the formation and maturation …

Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior

J Blundell, CA Blaiss, MR Etherton… - Journal of …, 2010 - Soc Neuroscience
Neuroligins (NLs) are a family of neural cell-adhesion molecules that are involved in
excitatory/inhibitory synapse specification. Multiple members of the NL family (including …

A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export

C Zhang, JM Milunsky, S Newton, J Ko… - Journal of …, 2009 - Soc Neuroscience
Neuroligins (NLs) are postsynaptic cell-adhesion molecules essential for normal synapse
function. Mutations in neuroligin-4 (NL4)(gene symbol: NLGN4) have been reported in some …

A neuroligin-3 mutation implicated in autism causes abnormal aggression and increases repetitive behavior in mice

EL Burrows, L Laskaris, L Koyama, L Churilov… - Molecular autism, 2015 - Springer
Background Aggression is common in patients with autism spectrum disorders (ASD) along
with the core symptoms of impairments in social communication and repetitive behavior …

Neuroligins determine synapse maturation and function

F Varoqueaux, G Aramuni, RL Rawson, R Mohrmann… - Neuron, 2006 - cell.com
Synaptogenesis, the generation and maturation of functional synapses between nerve cells,
is an essential step in the development of neuronal networks in the brain. It is thought to be …

Neuroligin‐3‐deficient mice: model of a monogenic heritable form of autism with an olfactory deficit

K Radyushkin, K Hammerschmidt… - Genes, Brain and …, 2009 - Wiley Online Library
Autism spectrum disorder (ASD) is a frequent neurodevelopmental disorder characterized
by variable clinical severity. Core symptoms are qualitatively impaired communication and …

Possible implication of the CA2 hippocampal circuit in social cognition deficits observed in the neuroligin 3 knock-out mouse, a non-syndromic animal model of autism

B Modi, D Pimpinella, A Pazienti, P Zacchi… - Frontiers in …, 2019 - frontiersin.org
Autism spectrum disorders (ASDs) comprise a heterogeneous group of neuro-
developmental abnormalities with a strong genetic component, characterized by deficits in …

Control of excitatory and inhibitory synapse formation by neuroligins

B Chih, H Engelman, P Scheiffele - Science, 2005 - science.org
The normal function of neural networks depends on a delicate balance between excitatory
and inhibitory synaptic inputs. Synapse formation is thought to be regulated by bidirectional …

Neuroligins and neurodevelopmental disorders: X-linked genetics

TA Nguyen, AW Lehr, KW Roche - Frontiers in Synaptic Neuroscience, 2020 - frontiersin.org
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that results in social-
communication impairments, as well as restricted and repetitive behaviors. Moreover, ASD …