Raf kinase inhibitor protein (RKIP) is a major negative mediator of the extracellular signal-
related kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway. The …

Increased levels of the proapoptotic kinase PKR have recently been detected in the brains of
patients with Alzheimer's disease, Parkinson's disease, Huntington's disease, HIV, dementia …

Receptor-interacting protein kinase 1 (RIPK1) is up-regulated in patients with
neurodegenerative diseases. Our study aimed to explore the underlying mechanisms that …

In 1984, a cytosolic protein was isolated from bovine brain and coined
phosphatidylethanolamine binding protein (PEBP) to describe its phospholipid-binding …

Neuropathological lesions in Alzheimer's disease (AD) include amyloid plaques formed by
the accumulation of amyloid peptides, neurofibrillary tangles made of hyperphosphorylated …

RKIP-1 is a metastasis suppressor that is frequently downregulated in aggressive cancers.
However, the consequences of RKIP loss in primary or immortalized cells have not yet been …

From its discovery as a phosphatidylethanolamine‐binding protein in bovine brain to its
designation as a physiological inhibitor of Raf kinase protein, RKIP has emerged as a critical …

An inverse association between cancer and neurodegeneration is plausible because these
biological processes share several genes and signaling pathways. Whereas uncontrolled …

The molecular mechanisms responsible for the loss of dopaminergic neurons in Parkinson's
disease (PD) remain obscure. Loss of function of E3 ubiquitin ligases is associated with …

Introduction• Control of translation• Dysfunctions of protein synthesis mediated by PKR‐and
mTOR‐dependent signalling pathways• Crosslink between the up‐regulation of PKR/eIF2α …