Posttranslational modification (PTM) is a term that implies dynamic modification of proteins
after their translation. PTM is involved not only in homeostasis but also in pathologic …

Diverse aetiological factors, including myocardial infarction, hypertension and contractile
abnormalities, trigger a cardiac remodelling process in which the heart becomes abnormally …

Histone deacetylase (HDAC) is recognized as one of the promising targets for cancer
treatment as many HDAC inhibitors have entered clinical trials for both solid and liquid …

Abstract Background Histone deacetylases (HDACs), important epigenetic regulatory
enzymes, can reduce cardiac hypertrophy and cardiac fibrosis. However, the mechanisms …

Deregulation of protein post-translational modifications is intensively involved in the etiology
of diseases, including degenerative diseases, inflammatory injuries, and cancers …

The adult heart responds to acute and chronic stresses by a remodelling process that is
accompanied by myocyte hypertrophy, impaired contractility, and pump failure, often …

Importance of the field: Histone deacetylase (HDAC) inhibitors are being developed as a
new, targeted class of anticancer drugs. Area covered in this review: This review focuses on …

Histone deacetylase (HDAC) inhibitors are emerging as an exciting new class of potential
anticancer agents for the treatment of solid and hematological malignancies. In recent years …

Histone deacetylases (HDACs) are enzymes that balance the acetylation activities of histone
acetyltransferases on chromatin remodeling and play essential roles in regulating gene …

Introduction HDACs catalyze the removal of acetyl groups from the ε-N-acetylated lysine
residues of various protein substrates including both histone and nonhistone proteins …