Dendrimers, distinguished by their mono-dispersed globular or spheroid macromolecular
structures with repeated branches, exhibit unique and desirable characteristics that set them …

Since the first dendrimer was reported in 1978 by Fritz Vögtle, dendrimer research has
grown exponentially, from synthesis to application in the past four decades. The distinct …

This review discusses recent studies on dendrimer-based nanoparticles in cancer
chemotherapy and gene therapy. In order to achieve the high efficacy and low side effects of …

Cancer immunotherapy has been researched as a major modality of treatment which
involves activating the immune system of the patient to fight against tumor cells. Dendrimers …

Importance of the field: Dendrimers are synthetic macromolecules with well-defined
structures, many terminal functional groups, and an inner space to hold small molecules …

Nanoscale size, a multi-functionalized surface, high branching, a cavernous interior, and
other distinctive structural features of dendrimers make them perfect drug delivery systems …

Chemotherapy is the first choice in the treatment of cancer and is always preferred to other
approaches such as radiation and surgery, but it has never met the need of patients for a …

Highlights•Dendrimers are nanovectors with well-defined architecture and tunable surface
characteristics.•Dendrimers can take advantage of passive and active tumor targeting for …

Dendrimers are nanoparticles with unique features including globular 3D shape and
nanometer size. The availability of numerous terminal functional groups and modifiable …

Dendrimers in nanobiomedicine have attracted attention to overcome the biological barriers
because of their suitable characteristics such as nanosize, hyperbranching polymeric …