Protein kinase CK2 is a potential target for the discovery of anticancer drugs. Flavonoids are
reported to be effective CK2 inhibitors. Herein, based on structural trimming of flavonoids, a …

Two classes of modified analogs of 4-(thiazol-5-yl) benzoic acid-type CK2 inhibitors were
designed. The azabenzene analogs, pyridine-and pyridazine-carboxylic acid derivatives …

Protein kinase CK2 is a potential drug target for many diseases including cancer and
inflammation disorders. The crystal structure of clinical candidate CX-4945 1 with CK2 …

Selective inhibitors of protein kinase CK2 with significant cytotoxicity on tumor cells based
on a 2-aminothiazole scaffold were described recently. Here, these studies are …

Protein kinase CK2 (CK2) is a ubiquitous serine/threonine protein kinase for hundreds of
endogenous substrates. CK2 has been considered to be involved in many diseases …

Herein we describe the synthesis and properties of substituted phenylaminopyrrolo [1, 2-a]
quinoxaline-carboxylic acid derivatives as a novel class of potent inhibitors of the human …

Protein kinase CK2 has emerged as an attractive cancer therapeutic target. Previous studies
have highlighted the challenge of optimizing CK2 ATP-competitive inhibitors that have low …

Abstract Protein kinase 2 (CK2), a member of the serine/threonine kinase family, has been
established as a promising target in anticancer therapy. New derivatives of known CK2 …

Multifunctional entities have recently been attractive for the development of anticancer
chemotherapeutic drugs. However, such entities with concurrent CK2 along with cancer …

Abstract Background Casein kinase 2 (CK2) is dysregulated in various human cancers and
is a promising target for cancer therapy. To date, there is no small molecular CK2 inhibitor in …