Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets
HF Tsai, PN Hsu - Journal of biomedical science, 2017 - Springer
Immune checkpoints or coinhibitory receptors, such as cytotoxic T lymphocyte antigen
(CTLA)-4 and programmed death (PD)-1, play important roles in regulating T cell responses …
(CTLA)-4 and programmed death (PD)-1, play important roles in regulating T cell responses …
Immune checkpoint blockade opens a new way to cancer immunotherapy
S Sadreddini, B Baradaran… - Journal of cellular …, 2019 - Wiley Online Library
Among the main promising systems to triggering therapeutic antitumor immunity is the
blockade of immune checkpoints. Immune checkpoint pathways regulate the control and …
blockade of immune checkpoints. Immune checkpoint pathways regulate the control and …
Checkpoint blockade for cancer therapy: revitalizing a suppressed immune system
YP de Coaña, A Choudhury, R Kiessling - Trends in molecular medicine, 2015 - cell.com
Immune checkpoint receptors are crucial molecules for fine-tuning immune responses.
Checkpoint signaling dampens T cell activation to avoid autoimmunity and the destructive …
Checkpoint signaling dampens T cell activation to avoid autoimmunity and the destructive …
Keeping tumors in check: a mechanistic review of clinical response and resistance to immune checkpoint blockade in cancer
N Borcherding, R Kolb, J Gullicksrud, P Vikas… - Journal of molecular …, 2018 - Elsevier
Immune checkpoints are a diverse set of inhibitory signals to the immune system that play a
functional role in adaptive immune response and self-tolerance. Dysregulation of these …
functional role in adaptive immune response and self-tolerance. Dysregulation of these …
Next generation of immune checkpoint inhibitors and beyond
JA Marin-Acevedo, EMO Kimbrough, Y Lou - Journal of hematology & …, 2021 - Springer
The immune system is the core defense against cancer development and progression.
Failure of the immune system to recognize and eliminate malignant cells plays an important …
Failure of the immune system to recognize and eliminate malignant cells plays an important …
Diversity of immune checkpoints in cancer immunotherapy
Z Guo, R Zhang, AG Yang, G Zheng - Frontiers in Immunology, 2023 - frontiersin.org
Finding effective treatments for cancer remains a challenge. Recent studies have found that
the mechanisms of tumor evasion are becoming increasingly diverse, including abnormal …
the mechanisms of tumor evasion are becoming increasingly diverse, including abnormal …
Novel immune checkpoint targets: A promising therapy for cancer treatments
M Patwekar, N Sehar, F Patwekar, A Medikeri… - International …, 2024 - Elsevier
The immune system frequently comprises immunological checkpoints. They serve as a
barrier to keep the immune system from overreacting and damaging cells that are robust …
barrier to keep the immune system from overreacting and damaging cells that are robust …
[HTML][HTML] Resistance to checkpoint inhibition in cancer immunotherapy
L Barrueto, F Caminero, L Cash, C Makris… - Translational …, 2020 - Elsevier
The interaction of the host immune system with tumor cells in the tissue microenvironment is
essential in understanding tumor immunity and development of successful cancer …
essential in understanding tumor immunity and development of successful cancer …
Tumor immune checkpoints and their associated inhibitors
Z Gao, X Ling, C Shi, Y Wang, A Lin - Journal of Zhejiang University …, 2022 - Springer
Immunological evasion is one of the defining characteristics of cancers, as the immune
modification of an immune checkpoint (IC) confers immune evasion capabilities to tumor …
modification of an immune checkpoint (IC) confers immune evasion capabilities to tumor …
The role of immune checkpoints in antitumor response: a potential antitumor immunotherapy
LV Mejía-Guarnizo, PS Monroy-Camacho… - Frontiers in …, 2023 - frontiersin.org
Immunotherapy aims to stimulate the immune system to inhibit tumor growth or prevent
metastases. Tumor cells primarily employ altered expression of human leukocyte antigen …
metastases. Tumor cells primarily employ altered expression of human leukocyte antigen …
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