The HO-1 isoenzyme is an early stress response gene regulated by many forms of oxidative
stress. The HO-2 isoenzyme is predominantly a constitutive enzyme, which may serve to …

Reactive oxygen species (ROS) were once considered to be deleterious agents,
contributing to a vast range of pathologies. But, now their protective effects are being …

Heme oxygenase (HO)-1 is the inducible isoform of the rate-limiting enzyme of heme
degradation. HO regulates the cellular content of the pro-oxidant heme and produces …

Understanding of redox signaling requires data on the spatiotemporal distribution of
hydrogen peroxide (H2O2) within the cell. The fluorescent reporter HyPer is a powerful …

Reactive oxygen species (ROS) have long been branded as undesired cytotoxic
compounds to be avoided at all costs. This view has changed with the realization that ROS …

There are many situations of excessive production of reactive oxygen species (ROS) such
as radiation, ischemia/reperfusion (I/R), and inflammation. ROS contribute to and arises from …

Hydrogen peroxide (H2O2) is steadily gaining more attention in the field of molecular
biology research. It is a major REDOX (reduction–oxidation reaction) metabolite and at high …

Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …

Hydrogen peroxide (H2O2) acts as a second messenger that can mediate intracellular
signal transduction via chemoselective oxidation of cysteine residues in signaling proteins …

Heme-oxygenase is the enzyme responsible for degradation of endogenous iron
protoporphyirin heme; it catalyzes the reaction's rate-limiting step, resulting in the release of …