Naturally arising CD25+ CD4+ regulatory T (Treg) cells, most of which are produced by the
normal thymus as a functionally mature T‐cell subpopulation, play key roles in the …

Abstract Naturally arising CD25+ CD4+ regulatory T cells, which express the transcription
factor Foxp3, play key roles in themaintenance of immunologic self-tolerance and negative …

Self-tolerance, the state of unresponsiveness to self-tissues/antigens, is maintained through
central and peripheral tolerance mechanisms, and a breach of these mechanisms leads to …

Human regulatory T cells (Tregs) expressing the transcription factor FoxP3 play
indispensable roles for the maintenance of immunological self‐tolerance and immune …

CD4+ CD25+ FOXP3+ regulatory T-cells (Tregs) form an important arm of the immune
system responsible for suppressing untoward immune responses. Tregs can be thymically …

A lack of regulatory T (TReg) cells that express CD4, CD25 and forkhead box P3 (FOXP3)
results in severe autoimmunity in both mice and humans. Since the discovery of TReg cells …

The suppressive/immunomodulatory function of CD4+ CD25+ FOXP3+ regulatory T (Treg)
cells is crucial for the maintenance of immune homeostasis, which helps to prevent …

Several immune cell subsets contribute to the maintenance of peripheral tolerance by taking
active participation in the networks that suppress autoreactive immune responses. There is …

Despite the skepticism that once prevailed among immunologists, it is now widely accepted
that the normal immune system harbors a T-cell population, called regulatory T cells (Treg …

Foxp3+ regulatory T lymphocytes (Treg) are critical homeostatic regulators of immune and
inflammatory responses. Their absence leads to fulminant multiorgan autoimmunity. This …