Gold (III) complexes as potential antitumor agents: solution chemistry and cytotoxic properties of some selected gold (III) compounds

L Messori, F Abbate, G Marcon, P Orioli… - Journal of medicinal …, 2000 - ACS Publications
Gold (III) complexes generally exhibit interesting cytotoxic and antitumor properties, but until
now, their development has been heavily hampered by their poor stability under …

[PDF][PDF] Gold (III) compounds as new family of anticancer drugs

L Messori, G Marcon, P Orioli - Bioinorganic chemistry and …, 2003 - Wiley Online Library
Gold (III) complexes are emerging asa new class of metal complexes with outstanding
cytotoxic properties and are presently being evaluated as potential antitumor agents. This …

Antitumor properties of some 2-[(dimethylamino) methyl] phenylgold (III) complexes

RG Buckley, AM Elsome, SP Fricker… - Journal of medicinal …, 1996 - ACS Publications
Four analogues of the gold (III) complex [AuCl2 (damp)](1)(damp= 2-[(dimethylamino)
methyl] phenyl) have been evaluated for antitumor activity. The compounds have structural …

Synthesis, structural characterization, solution behavior, and in vitro antiproliferative properties of a series of gold complexes with 2-(2′-pyridyl) benzimidazole as …

M Serratrice, MA Cinellu, L Maiore, M Pilo… - Inorganic …, 2012 - ACS Publications
A variety of gold (III) and gold (I) derivatives of 2-(2′-pyridyl) benzimidazole (pbiH) were
synthesized and fully characterized and their antiproliferative properties evaluated in a …

Gold (III) compounds as anticancer drugs

C Gabbiani, A Casini, L Messori - Gold Bulletin, 2007 - Springer
Gold (III) complexes constitute a new class of metallodrugs, of potential interest for cancer
treatment. During the past decade different kinds of gold (III) complexes have been reported …

Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold (III) compounds for cancer treatment: a systematic study

A Casini, G Kelter, C Gabbiani, MA Cinellu… - JBIC Journal of …, 2009 - Springer
The antiproliferative properties of a group of 13 structurally diverse gold (III) compounds,
including six mononuclear gold (III) complexes, five dinuclear oxo-bridged gold (III) …

Gold coordination complexes as anticancer agents.

I Kostova - Anti-cancer agents in medicinal chemistry, 2006 - europepmc.org
Metal ions are known to bind with nucleic acids and thereby alter their conformation and
biological function. The metal ion-base interaction depends on the nature of both metal and …

Gold (III) complexes with bipyridyl ligands: solution chemistry, cytotoxicity, and DNA binding properties

G Marcon, S Carotti, M Coronnello… - Journal of Medicinal …, 2002 - ACS Publications
Gold (III) compounds generally exhibit significant cytotoxic effects on cancer cell lines and
are of potential interest as antitumor drugs. We report here on the solution chemistry, the …

Correlation of the in vitro cytotoxic and in vivo antitumor activities of gold (I) coordination complexes

CK Mirabell, RK Johnson, DT Hill… - Journal of medicinal …, 1986 - ACS Publications
Method A.[2, 3, 4, 6-Tetrakis-0-[(methylamino)-carbonyl]-l-thio-/JD-glucopyranosato-
S](triethyl-phosphine) gold (3). A mixture of 2 (5.2 g, 0.01 mol) and methyl isocyanate (100 g …

Chemical biology of anticancer gold (III) and gold (I) complexes

T Zou, CT Lum, CN Lok, JJ Zhang… - Chemical Society Reviews, 2015 - pubs.rsc.org
Gold complexes have recently gained increasing attention in the design of new metal-based
anticancer therapeutics. Gold (III) complexes are generally reactive/unstable under …