Chemoprevention studies of the flavonoids quercetin and rutin in normal and azoxymethane-treated mouse colon

K Yang, SA Lamprecht, Y Liu, H Shinozaki… - …, 2000 - academic.oup.com
In this study we investigated the chemopreventive effects of quercetin and rutin when added
to standard AIN-76A diet and fed to normal and azoxymethane (AOM)-treated mice. Early …

[HTML][HTML] Quercetin, but not its glycosidated conjugate rutin, inhibits azoxymethane-induced colorectal carcinogenesis in F344 rats

AA Dihal, VCJ de Boer, H van der Woude… - The Journal of …, 2006 - Elsevier
The effect of the flavonoid quercetin and its conjugate rutin was investigated on (biomarkers
of) colorectal cancer (CRC). Male F344 rats (n= 42/group) were fed 0, 0.1, 1, or 10 g …

Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia

EE Deschner, J Ruperto, G Wong… - …, 1991 - academic.oup.com
Dietary quercetin (QU) and rutin (RU), phenolic flavonoids commonly found in many fruits
and vegetables, were provided to CF1 female mice for 50 weeks to assess the ability of …

The effect of dietary quercetin and rutin on AOM‐induced acute colonic epithelial abnormalities in mice fed a high‐fat diet

EE Deschner, JF Ruperto, GY Wong, HL Newmark - 1993 - Taylor & Francis
Dietary quercetin (QU) and rutin (RU), phenolic flavonoids found in many fruits and
vegetables, when fed to mice on a low‐fat diet successfully modified the response to …

[HTML][HTML] Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis

CA Warren, KJ Paulhill, LA Davidson, JR Lupton… - The Journal of …, 2009 - Elsevier
The flavonoid quercetin suppresses cell proliferation and enhances apoptosis in vitro. In this
study, we determined whether quercetin protects against colon cancer by regulating the …

Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats

T Leonardi, J Vanamala, SS Taddeo… - Experimental …, 2010 - journals.sagepub.com
Epidemiological evidence suggests that a diet abundant in fruits and vegetables may protect
against colon cancer. Bioactive compounds, including flavonoids and limonoids, have been …

Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells

SM Kuo - Cancer letters, 1996 - Elsevier
Dietary flavonoids are known to be antiproliferative and may play an important role in cancer
chemoprevention, especially cancers of the gastrointestinal tract, because of a direct contact …

Suppression of intestinal crypt cell proliferation and aberrant crypt foci by dietary quercetin in rats

JM Gee, H Hara, IT Johnson - Nutrition and cancer, 2002 - Taylor & Francis
Quercetin inhibits proliferation of human gastric and colonic cancer cells in vitro by
suppressing mitosis and increasing apoptosis. Quercetin might therefore act as an …

Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin.

T Tanaka, H Makita, K Kawabata, H Mori… - …, 1997 - academic.oup.com
The modulating effects of dietary feeding of two flavonoids, diosmin and hesperidin, both
alone and in combination, during the initiation and post-initiation phases on colon …

Quercetin's Effects on Intestinal Polyp Multiplicity and Macrophage Number in the Apc Min/+ Mouse

EA Murphy, JM Davis, JL McClellan… - Nutrition and …, 2011 - Taylor & Francis
Numerous in vitro studies argue for quercetin's chemopreventive potential in colon cancer;
however, experimental studies in rodents are limited. Macrophages play a role in …