Citrus limonoids obacunone and limonin inhibit azoxymethane‐induced colon carcinogenesis in rats

T Tanaka, H Kohno, Y Tsukio, S Honjo, M Tanino… - Biofactors, 2000 - Wiley Online Library
Obacunone and limonin are bitter limonoids in citrus. Their modifying effects on the
development of aberrant crypt foci (ACF), the activity of detoxification enzymes, glutathione S …

Increased induction of aberrant crypt foci by 1, 2-dimethylhydrazine in rats fed diets containing purified genistein or genistein-rich soya protein

JM Gee, H Noteborn, ACJ Polley, IT Johnson - Carcinogenesis, 2000 - academic.oup.com
The isoflavonoid genistein inhibits mitosis and increases apoptosis in a variety of tumour cell
lines in vitro, and may exert anticarcinogenic effects in vivo. To assess its effects on the …

Lack of chemopreventive effects of ginger on colon carcinogenesis induced by 1, 2-dimethylhydrazine in rats

MC Dias, ALT Spinardi-Barbisan… - Food and chemical …, 2006 - Elsevier
Ginger (Zingiber officinale Roscoe) has been proposed as a promising candidate for cancer
prevention. Its modifying potential on the process of colon carcinogenesis induced by 1, 2 …

A preliminary investigation demonstrating the effect of quercetin on the expression of genes related to cell‐cycle arrest, apoptosis and xenobiotic metabolism in human …

I Murtaza, G Marra, R Schlapbach… - Biotechnology and …, 2006 - Wiley Online Library
The role of the natural dietary flavonoid chemical quercetin (an antioxidant) in the prevention
and treatment of colon cancer is receiving a great deal of attention. However, little is known …

The antitumor activities of flavonoids

C Kanadaswami, LT Lee, PPH Lee, JJ Hwang, FC Ke… - In vivo, 2005 - iv.iiarjournals.org
The flavonoids are polyphenolic compounds found as integral components of the human
diet. They are universally present as constituents of flowering plants, particularly of food …

Citrus auraptene inhibits chemically induced colonic aberrant crypt foci in male F344 rats.

T Tanaka, K Kawabata, M Kakumoto, H Makita… - …, 1997 - academic.oup.com
The modifying effect of dietary administration of auraptene isolated from the peel of citrus
fruit (Citrus natsudaidai Hayata) on the development of azoxymethane (AOM)-induced …

(−)-Epigallocatechin Gallate Suppresses Azoxymethane-Induced Colonic Premalignant Lesions in Male C57BL/KsJ-db/db Mice

M Shimizu, Y Shirakami, H Sakai, S Adachi… - Cancer Prevention …, 2008 - AACR
Obesity and diabetes mellitus are risk factors for colon cancer. The activation of the insulin-
like growth factor (IGF)/IGF-IR axis plays a critical role in this carcinogenesis.(−) …

Cell proliferation in cancer prevention; effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human …

H Mori, K Niwa, Q Zheng, Y Yamada, K Sakata… - Mutation Research …, 2001 - Elsevier
Proto-oncogenes such as c-fos, c-jun and c-myc are known to relate to cell proliferation and
differentiation. Some oriental herbal medicines like Glycyrrhizae radix or Juzen-taiho-to …

Quercetin inhibits human DLD-1 colon cancer cell growth and polyamine biosynthesis

M Linsalata, A Orlando, C Messa, MG Refolo… - Anticancer …, 2010 - ar.iiarjournals.org
Background/Aim: Polyamines and ornithine decarboxylase are involved in cell growth and
differentiation. The polyphenol quercetin may exert anti-tumour properties by influencing …

Effect of dietary curcumin and ascorbyl palmitate on azoxymethanol-induced colonic epithelial cell proliferation and focal areas of dysplasia

MT Huang, EE Deschner, HL Newmark, ZY Wang… - Cancer letters, 1992 - Elsevier
Curcumin, a major yellow pigment of turmeric obtained from powdered rhizomes of the plant
Curcuma longa Linn., is commonly used as a coloring agent in foods, drugs and cosmetics …