A majority of proteins responsible for the establishment and maintenance of human disease
states are unable to be targeted therapeutically by molecules belonging to either of the two …

The development of constrained peptides represents an emerging strategy to generate
peptide based probes and hits for drug-discovery that address challenging protein–protein …

Stapled α-helical peptides represent an emerging superclass of macrocyclic molecules with
drug-like properties, including high-affinity target binding, protease resistance, and …

Highlights•We provide a SWOT analysis of peptide therapeutics and discuss commercial
aspects.•We comment on emerging peptide technologies and cell-penetrating peptides.• …

The concept of peptides as therapeutic agents has been historically disregarded by the
pharmaceutical industry on account of their susceptibility to degradation, their size and …

After many years of stagnation, peptide therapeutics once again became the focus of
innovative drug development efforts backed up by venture funds and biotechnology …

Although not complying with Lipinski's rule, peptides are to an increasing extent being
developed into new active pharmaceutical ingredients. This is mainly due to novel …

The decreasing number of approved drugs produced by the pharmaceutical industry, which
has been accompanied by increasing expenses for R&D, demands alternative approaches …

Recently disulfide-rich head-to-tail cyclic peptides have attracted the interest of medicinal
chemists owing to their exceptional thermal, chemical and enzymatic stability brought about …

Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …