Baseline cardiac parameters as biomarkers of radiation cardiotoxicity in lung cancer: an NI-HEART analysis

GM Walls, N Hill, M McMahon, B Kearney, C McCann… - Cardio Oncology, 2024 - jacc.org
Background Radiation-induced cardiotoxicity poses a significant challenge in lung cancer
management because of the close anatomical proximity of the heart to the lungs …

Cardiac radiation dose, cardiac disease, and mortality in patients with lung cancer

KM Atkins, B Rawal, TL Chaunzwa, N Lamba… - Journal of the American …, 2019 - jacc.org
Background: Radiotherapy-associated cardiac toxicity studies in patients with locally
advanced non–small cell lung cancer (NSCLC) have been limited by small sample size and …

Dosimetric predictors of cardiotoxicity in thoracic radiotherapy for lung cancer

JF Borkenhagen, C Bergom, CT Rapp… - Clinical Lung Cancer, 2019 - Elsevier
Background Higher cardiac radiotherapy (RT) doses when treating lung cancer are
associated with worse overall survival (OS), although the direct association between cardiac …

The association of incidental radiation dose to the heart base with overall survival and cardiac events after curative-intent radiotherapy for non-small cell lung cancer …

GM Walls, J O'Connor, M Harbinson, F Duane… - Clinical Oncology, 2024 - Elsevier
Aims Cardiac disease is a dose-limiting toxicity in non-small cell lung cancer radiotherapy.
The dose to the heart base has been associated with poor survival in multiple institutional …

Heart dosimetric analysis of three types of cardiac toxicity in patients treated on dose-escalation trials for Stage III non-small-cell lung cancer

K Wang, KA Pearlstein, ND Patchett, AM Deal… - Radiotherapy and …, 2017 - Elsevier
Background and purpose To assess associations between radiation dose/volume
parameters for cardiac subvolumes and different types of cardiac events in patients treated …

Predicting adverse cardiac events after radiotherapy for locally advanced non–small cell lung cancer

HJ No, FB Guo, NJI Park, N Kastelowitz, JW Rhee… - Cardio Oncology, 2023 - jacc.org
Background Radiotherapy may cause grade≥ 3 cardiac events, necessitating a better
understanding of risk factors. The potential predictive role of imaging biomarkers with …

Cardiac morbidity following chemoradiation in stage III non-small cell lung cancer patients: a population-based cohort study

EK Donovan, GR Pond, H Seow, PM Ellis… - Clinical Oncology, 2023 - Elsevier
Aims To assess the risk of cardiac toxicity following radical radiotherapy in advanced lung
cancer patients. Materials and methods Patients with a diagnosis of stage III non-small cell …

Predicting Radiation-Induced Heart Disease and Survival—Is Location the Key?

C Bergom, D Rayan, SA Brown - JAMA oncology, 2021 - jamanetwork.com
More than half of all patients with cancer receive radiation therapy. While radiation is a
critical component of cancer treatment for many malignancies, incidental cardiac radiation …

[HTML][HTML] Prediction models for treatment-induced cardiac toxicity in patients with non-small-cell lung cancer: A systematic review and meta-analysis

F Tohidinezhad, F Pennetta, J van Loon… - Clinical and …, 2022 - Elsevier
Background To maximize the likelihood of positive outcome in non-small-cell lung cancer
(NSCLC) survivors, potential benefits of treatment modalities have to be weighed against the …

[HTML][HTML] Prospective exploratory analysis of cardiac biomarkers and electrocardiogram abnormalities in patients receiving thoracic radiation therapy with high-dose …

DR Gomez, SW Yusuf, MF Munsell, JW Welsh… - Journal of Thoracic …, 2014 - Elsevier
Introduction Acute effects of incidental cardiac irradiation in patients treated for thoracic
cancer are not well characterized. We evaluated longitudinal changes in cardiac biomarkers …