On the basis of studies that extend back to the early 1900s, regression and stabilization of
atherosclerosis in humans has progressed from being a concept to one that is achievable …

High-density lipoprotein (HDL) particles transport (among other molecules) cholesterol (HDL-
C). In epidemiological studies, plasma HDL-C levels have an inverse relationship to the risk …

Looking back at animal and clinical studies published since the 1920s, the notion of rapid
regression and stabilization of atherosclerosis in humans has evolved from a fanciful goal to …

Considerable evidence from preclinical and population studies suggests that HDLs (high-
density lipoproteins) possess atheroprotective properties. Reports from HDL infusion studies …

Research into the management of dyslipidaemia has increasingly focussed on the
importance of high-density lipoprotein cholesterol (HDL‐C) levels. It is well known that low …

In a process often seen as progressive and irreversible, deposition and retention of
lipoproteins and the consequent inflammatory reaction result in the accumulation of …

Primary and secondary prevention of coronary heart disease (CHD) has focused on
lowering the LDL fraction of blood lipids not only because of the strong epidemiological …

Objective: HDL (high-density lipoprotein) role in atherosclerosis is controversial. Clinical
trials with CETP (cholesterylester transfer protein)-inhibitors have not provided benefit. We …

In the last six decades, high density lipoproteins (HDL) have been extensively considered to
reduce the risk for coronary artery disease (CAD); in fact, the cholesterol carried by HDL …

LDL-lowering therapies, predominantly involving statins, have been shown to significantly
reduce cardiovascular events in asymptomatic subjects as well as in subjects with clinically …