[HTML][HTML] Current state of the art in hypoplastic left heart syndrome

AK Birla, S Brimmer, WD Short, OO Olutoye… - Frontiers in …, 2022 - frontiersin.org
Hypoplastic left heart syndrome (HLHS) is a complex congenital heart disease in which a
neonate is born with an underdeveloped left ventricle and associated structures. Without …

Hypoplastic left heart syndrome (HLHS): molecular pathogenesis and emerging drug targets for cardiac repair and regeneration

AT Bejjani, N Wary, M Gu - Expert opinion on therapeutic targets, 2021 - Taylor & Francis
Introduction Hypoplastic left heart syndrome (HLHS) is a severe developmental defect
characterized by the underdevelopment of the left ventricle along with aortic and valvular …

Hypoplastic left heart syndrome: From bedside to bench and back

A Saraf, WM Book, TJ Nelson, C Xu - Journal of molecular and cellular …, 2019 - Elsevier
Abstract Hypoplastic Left Heart Syndrome (HLHS) is a complex Congenital Heart Disease
(CHD) that was almost universally fatal until the advent of the Norwood operation in 1981 …

Regenerative medicine strategies for hypoplastic left heart syndrome

J Chery, J Wong, S Huang, S Wang… - Tissue Engineering Part B …, 2016 - liebertpub.com
Hypoplastic left heart syndrome (HLHS), the most severe and common form of single
ventricle congenital heart lesions, is characterized by hypoplasia of the mitral valve, left …

The Potential Role of Regenerative Medicine on the Future Management of Hypoplastic Left Heart Syndrome

JM Kelly, C Anderson, CK Breuer - Journal of Cardiovascular …, 2022 - mdpi.com
The development and translation of regenerative medicine approaches for the treatment of
hypoplastic left heart syndrome (HLHS) provides a promising alternative to the current …

Hypoplastic left heart syndrome across the lifespan: clinical considerations for care of the fetus, child, and adult

RM Wald, LL Mertens - Canadian Journal of Cardiology, 2022 - Elsevier
Hypoplastic left heart syndrome (HLHS) is the most common anatomic lesion in children
born with single-ventricle physiology and is characterised by the presence of a dominant …

Hypoplastic Left Heart Syndrome: Signaling & Molecular Perspectives, and the Road Ahead

S Datta, W Cao, M Skillman, M Wu - International Journal of Molecular …, 2023 - mdpi.com
Hypoplastic left heart syndrome (HLHS) is a lethal congenital heart disease (CHD) affecting
8–25 per 100,000 neonates globally. Clinical interventions, primarily surgical, have …

Cell-based therapy to boost right ventricular function and cardiovascular performance in hypoplastic left heart syndrome: Current approaches and future directions

K Williams, A Khan, YS Lee, JM Hare - Seminars in perinatology, 2023 - Elsevier
Congenital heart disease remains one of the most frequently diagnosed congenital diseases
of the newborn, with hypoplastic left heart syndrome (HLHS) being considered one of the …

Hypoplastic left heart syndrome

S Mussa, DJ Barron - Paediatrics and Child Health, 2017 - Elsevier
Hypoplastic left heart syndrome is a rare congenital heart defect in which the left-sided heart
structures are underdeveloped, such that the left ventricle is unable to support the systemic …

Hypoplastic left heart syndrome: new insights

P Grossfeld - Circulation research, 2007 - Am Heart Assoc
20% to 25% of mortality in infants born with congenital heart disease. In the United States,
2000 infants are born each year with HLHS. 1 To date, there is a paucity of studies that …