Liver cancer is a critical clinical condition with augmented malignancy, rapid progression,
and poor prognosis. Liver cancer often initiates as fibrosis, develops as cirrhosis, and results …

The antiproliferative activity of phyllanthin (the major constituent in the decoction of
Phyllanthus niruri L.) against human liver carcinoma HepG2 cells, the mechanism of cell …

Background Phyllanthus amarus, a traditional herbal liver-protecting medicine, is known to
contain an active ingredient phyllanthin. Many research studies and clinical trials performed …

The ability to induce apoptosis is an important marker for cytotoxic antitumor agents. Some
natural compounds have been shown to modulate apoptosis pathways that are frequently …

Methotrexate (MTX) is an efficient chemotherapeutic and immunosuppressant drug, but the
hepatotoxicity of MTX limits its clinical use. Naringin (Nar) is a flavonoid derived from Citrus …

Background The liver plays an essential role in the body by regulating several important
metabolic functions. Liver injury is associated with the distortion of these functions causing …

Background: Phyllanthus (Euphorbiaceae) species have long been used in folk medicine to
treat various pathological conditions including liver diseases. Some species of Phyllanthus …

ETHNOPHARMACOLOGICAL RELEVANCE: Phyllanthus urinaria is widely used as anti-
inflammatory, anti-diarrheal and hepatoprotective medicines in Asian countries such as …

Phyllanthus species, especially P. amarus is a medicinal plant with hepatoprotective activity,
believed to occur in part by inhibiting hepatitis B virus function. The pathogenesis …

This study was designed to assess the preventive effects and to suggest the probable
mechanisms of action of quercetin and naringein in diethylnitrosamine (DEN)/2 …