The NOD-like receptor family, pyrin domain containing-3 (NLRP3) inflammasome has been
implicated in renal inflammation and fibrosis. However, the biological function of …

Cytoplasmic nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
forms an inflammasome with apoptosis-associated speck-like protein containing a CARD …

Proteinuria serves as a direct causative factor of renal tubular cell injury and is highly
associated with the progression of chronic kidney disease via uncertain mechanisms …

Metabolic syndrome (MS) is a group of complex metabolic disorders syndrome, which refers
to the pathological state of metabolism disorder of protein, fat, carbohydrate and other …

Background: We previously reported that the NLRP3 inflammasome played an important
role in mediating the podocyte injury induced by aldosterone. However, more studies on the …

Growing evidence has shown that NLRP3 inflammasome activation promotes the
development of tubulointerstitial inflammation and progression of renal injury. We previously …

Background and Aims. The nucleotide-binding domain and leucine-rich repeat containing
PYD-3 (NLRP3) inflammasome has been implicated in the pathogenesis of chronic kidney …

Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and
chronic kidney disease. NLRX1 is a receptor of the innate immune system that is …

Inflammasomes, multiprotein complex induced by harmful factors in the body, play a crucial
role in innate immunity. Activation of inflammasomes lead to the activation of casepase-1 …

Abstract Ischemia/reperfusion (I/R) is a critical risk factor for acute kidney injury (AKI). Recent
studies provided evidence that tubular epithelial cells (TEC)-associated inflammation …