Objective: To review the literature concerning the physiology of the endocannabinoid
system, current drug development of cannabinoid agonists, and current clinical research on …

Cannabinoids have been used to treat pain for many centuries. However, only during the
past several decades have rigorous scientific methods been applied to understand the …

Research on the therapeutic potential of cannabinoids has grown dramatically over the past
few years. Recent advances include evidence that cannabinoid agonists are …

Convincing evidence frompreclinical studies demonstrates that cannabinoids can
reducepain responses ina rangeof inflammatory and neuropathicpain models. The …

A large body of literature indicates that cannabinoids suppress behavioral responses to
acute and persistent noxious stimulation in animals. This review exax mines …

This article reviews recent research on cannabinoid analgesia via the endocannabinoid
system and non-receptor mechanisms, as well as randomized clinical trials employing …

Recent advances have dramatically increased our understanding of cannabinoid
pharmacology: the psychoactive constituents of Cannabis sativa have been isolated …

During the last decade, rigorous scientific methods have been applied to determine the
effects of cannabinoids on nociceptive neurotransmission. Cannabinoids have been …

Cannabis sativa is one of the oldest crops cultivated for the production of fibers and for
medical and recreational purposes. Since the detection of specific cannabinoid receptors …

Modern pharmacology of cannabinoids began in 1964 with the isolation and partial
synthesis of delta‐9‐tetrahydrocannabinol, the main psychoactive agent in herbal cannabis …