In vivo and in vitro studies have demonstrated that P-glycoprotein (P-gp) plays a very
significant role in the ADME processes (absorption, distribution, metabolism, excretion) and …

The multi-drug resistant transporter MDR1/P-glycoprotein, the gene product of MDR1, is a
glycosylated membrane protein of 170 kDa, belonging to the ATP-binding cassette (ABC) …

Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …

Human P-glycoprotein (P-gp) is encoded by the MDR1 gene, which is located on
chromosomal region 7q21 and consists of 28 exons. To date, over 50 single nucleotide …

The multidrug resistance (MDR1) gene product P-glycoprotein is a membrane protein that
functions as an ATP-dependent efflux pump, transporting exogenous and endogenous …

The human multidrug resistance gene (MDR1), spanning greater than 200 kb, encodes for
the ATP-dependent membrane efflux transporter, P-glycoprotein (Pgp). Significant progress …

There exists a marked inter-individual variability of P-glycoprotein expression and activity,
which can be of clinical importance due to the large number of drugs that are substrates for …

P-glycoprotein (P-gp), the protein product of MDR1 gene, is an important factor regulating
the bioavailability of many therapeutics. Recently, the C3435T polymorphism of MDR1 was …

P-glycoprotein (P-gp) is a transmembrane transporter playing an important role in drug
efflux. There is growing evidence that P-gp activity may be related to haplotypes of MDR1 …

The objective of this study was to develop a real-time polymerase chain reaction (PCR)
method to detect MDR1 (human multidrug resistance gene) single nucleotide …