Background Primaquine is used to prevent Plasmodium vivax relapse; however, it is not
implemented in many malaria-endemic countries, including Cambodia, for fear of …

Background Primaquine is currently the only medication used for radical cure of
Plasmodium vivax infection. Unfortunately, its use is not without risk. Patients with glucose-6 …

BACkGROunD Primaquine is currently the only medicine for treating relapses of
Plasmodium vivax and P. ovale malaria, due to its specific activity against malaria …

Background Primaquine is essential for the radical cure of vivax malaria, however its broad
application is hindered by the risk of drug-induced haemolysis in individuals with glucose-6 …

Background The WHO recommends single low-dose primaquine (SLDPQ, 0.25 mg/kg body
weight) in falciparum-infected patients to block malaria transmission and contribute to …

Radical cure of Plasmodium vivax malaria in glucose-6-phosphate dehydrogenase (G6PD)
deficient individuals employs weekly primaquine dosing. This is the only recommended …

Background Malaria causes a reduction in haemoglobin that is compounded by primaquine,
particularly in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The …

Background Primaquine (PQ) actively clears mature Plasmodium falciparum gametocytes
but in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals can cause …

Safe treatment of Plasmodium vivax requires diagnosis of both the infection and status of
erythrocytic glucose-6-phosphate dehydrogenase (G6PD) activity because hypnozoitocidal …

Background Plasmodium vivax malaria, with the widest geographic distribution, can cause
severe disease and death. Primaquine is the main licensed antimalarial drug that can kill …