Abstract Alpha-1-antitrypsin (α 1 AT) is one of several protease inhibitors in serum which
together control proteases involved in such vital processes as activation of the clotting …

Alpha-1-antitrypsin (A1AT) deficiency is an autosomal hereditary disorder associated with a
major reduction in serum A1AT levels. Clinically, A1AT deficiency is associated with …

The liver is the primary site of synthesis of alpha-1-antitrypsin (AAT) protein, although it is
also made in enterocytes and some mononuclear white blood cells. 1 Large quantities of …

Alpha-1-antitrypsin (AT) deficiency was first described in the late 1960s by Laurell and
Eriksson [1] in patients with severe pulmonary emphysema. The recognition of AT deficiency …

Two disparate disease states—an adult form of emphysema and a childhood form of liver
cirrhosis—have been linked to an inherited absence of this antienzyme. In their severe …

ABSTRACT α1-antitrypsin (α1AT) deficiency is a common lethal hereditary disorder of white
persons of European descent. The condition is characterized by reduced serum levels of α …

α1-Antitrypsin (AAT), a 52 kDa plasma protein, is produced mainly in the liver. It is the most
abundant circulating ser ine p roteinase in hibitor (serpin). It has also previously been called …

Extremely deficient levels of α-1-antitrypsin (α1AT) predispose such deficientindividuals to
the development of emphysema and cirrhosis. Protease inhibitor (Pi) typing has clarified that …

A prospective screening program was undertaken at the Royal Free Hospital, London, to
ascertain the incidence of α-1-antitrypsin (AAT) deficiency in patients with liver disease …

Alpha-I-antitrypsin (oilAT) is an acute phase reacting a1 globulin synthesized by cells (most
notably the hepatocyte) for protection against tissue injury. This response is assumed to …