Inflammation has been implicated as a secondary injury mechanism following ischemia and
stroke. A variety of experimental models, including thromboembolic stroke, focal and global …

Stroke remains the number one cause of morbidity in the United States. Within weeks to
months after an ischemic event, there is a resolution of inflammation and evidence of …

Ischemia elicits an inflammatory response in the injured brain that is mediated by various
factors, leading to the accumulation of inflammatory cells. These cells, in turn, generate both …

Microglia-associated neuroinflammation plays an important role in the pathophysiology of
ischemic stroke. Microglial activation and polarization, and the inflammatory response …

For the last two decades, researchers have placed hopes in a new era in which a
combination of reperfusion and neuroprotection would revolutionize the treatment of stroke …

Ischaemic stroke elicits a strong neuroinflammatory response, but the functional relevance
and therapeutic potential of neuroinflammation has only recently become apparent. In acute …

Contrary to previous dogmas, it is now well established that brain cells can produce
cytokines and chemokines, and can express adhesion molecules that enable an in situ …

Historically, the brain has been considered an immune-privileged organ separated from the
peripheral immune system by the blood–brain barrier. However, immune responses do …

Ischemic stroke is one of the main issues threatening human health worldwide, and it is also
the main cause of permanent disability in adults. Energy consumption and hypoxia after …

Stroke, in association with its complications, is one of the leading causes of mortality and
morbidity worldwide. Cerebral ischemia triggers an inflammatory response in the brain that …