Fragment-based approaches to finding novel small molecules that bind to proteins are now
firmly established in drug discovery and chemical biology. Initially developed primarily in a …

1.1. Fragments. The central idea in fragment-based discovery is that screening a target
against a small number (as few as 500 compounds) of low molecular weight compounds …

Finding novel compounds as starting points for optimization is a major challenge in drug
discovery research. Fragment-based methods have emerged in the past ten years as an …

Fragment-based approaches have now become firmly established in the drug discovery
armoury. After notable early successes against protein kinases, the versatility and power of …

The field of fragment-based drug discovery (FBDDa) has developed significantly over the
past 10 years and is now recognized as a tangible alternative to more traditional methods of …

Fragment-based drug discovery (FBDD) concerns the screening of low-molecular weight
compounds against macromolecular targets of clinical relevance. These compounds act as …

Fragment based drug design has emerged as an effective alternative to high throughput
screening for the identification of lead compounds in drug discovery in the past fifteen years …

A “fragment hit”, a molecule of low molecular weight that has been validated to bind to a
target protein, can be an effective chemical starting point for a drug discovery project. Our …

Fragment-based lead discovery (FBLD) has become a pillar in drug development. Typical
applications of this method comprise at least two biophysical screens as prefilter and a …

Fragment-based drug discovery (FBDD) is a powerful method to develop potent small-
molecule compounds starting from fragments binding weakly to targets. As FBDD exhibits …