Multifaceted roles of chemokines and chemokine receptors in tumor immunity

K Matsuo, O Yoshie, T Nakayama - Cancers, 2021 - mdpi.com
Simple Summary Various immune cells are involved in host immune responses to cancer. T-
helper (Th) 1 cells, cytotoxic CD8+ T cells, and natural killer cells are the major effector cells …

Chemokines and their receptors: multifaceted roles in cancer progression and potential value as cancer prognostic markers

HTT Do, CH Lee, J Cho - Cancers, 2020 - mdpi.com
Chemokines are chemotactic cytokines that mediate immune cell chemotaxis and lymphoid
tissue development. Recent advances have indicated that chemokines and their cognate …

The role of chemokines in cancer immune surveillance by the adaptive immune system

C Krieg, O Boyman - Seminars in cancer biology, 2009 - Elsevier
Chemokines are key molecules involved in the migration and homeostasis of immune cells.
However, also tumor cells use chemokine signals for different processes such as tumor …

Chemokines and chemokine receptors: new targets for cancer immunotherapy

V Mollica Poeta, M Massara, A Capucetti… - Frontiers in …, 2019 - frontiersin.org
Immunotherapy is a clinically validated treatment for many cancers to boost the immune
system against tumor growth and dissemination. Several strategies are used to harness …

Key chemokines direct migration of immune cells in solid tumors

K Kohli, VG Pillarisetty, TS Kim - Cancer gene therapy, 2022 - nature.com
Immune cell infiltration into solid tumors, their movement within the tumor microenvironment
(TME), and interaction with other immune cells are controlled by their directed migration …

Chemokines in cancer

MT Chow, AD Luster - Cancer immunology research, 2014 - AACR
Chemokines are chemotactic cytokines that control the migration of cells between tissues
and the positioning and interactions of cells within tissue. The chemokine superfamily …

Chemokines and the immune response to cancer

AJ Ozga, MT Chow, AD Luster - Immunity, 2021 - cell.com
Chemokines are chemotactic cytokines that regulate the migration of immune cells.
Chemokines function as cues for the coordinated recruitment of immune cells into and out of …

Chemokines and chemokine receptors: orchestrating tumor metastasization

E Marcuzzi, R Angioni, B Molon, B Calì - International journal of molecular …, 2018 - mdpi.com
Metastasis still represents the primary cause of cancer morbidity and mortality worldwide.
Chemokine signalling contributes to the overall process of cancer growth and metastasis …

Chemokines modulate immune surveillance in tumorigenesis, metastasis, and response to immunotherapy

AE Vilgelm, A Richmond - Frontiers in immunology, 2019 - frontiersin.org
Chemokines are small secreted proteins that orchestrate migration and positioning of
immune cells within the tissues. Chemokines are essential for the function of the immune …

Beyond cell motility: the expanding roles of chemokines and their receptors in malignancy

D Morein, N Erlichman, A Ben-Baruch - Frontiers in immunology, 2020 - frontiersin.org
The anti-tumor activities of some members of the chemokine family are often overcome by
the functions of many chemokines that are strongly and causatively linked with increased …