The G Protein-Coupled Estrogen Receptor (GPER) is a novel membrane-bound receptor
that mediates non-genomic actions of the primary female sex hormone 17β-estradiol …

Activation of G protein-coupled estrogen receptor (GPER) by its agonist, G1, protects the
heart from stressors such as pressure-overload, ischemia, a high-salt diet, estrogen loss …

A key to harnessing the enormous therapeutic potential of estrogens is understanding the
diversity of estrogen receptors and their signaling mechanisms. In addition to the classic …

Heart disease in women remains underappreciated, underdiagnosed and undertreated.
Further, although we are starting to understand some of the social and behavioral …

Oxidative stress has been implicated in the unfavorable changes in cardiac function and
remodeling that occur after ovarian estrogen loss. Using ovariectomized rat models, we …

Cardiovascular Diseases (CVDs) are the leading cause of death globally. More than 17
million people die worldwide from CVD per year. There is considerable evidence suggesting …

Estrogen has a plethora of effects in the cardiovascular system. Studies of estrogen and the
heart span human clinical trials and basic cell and molecular investigations. Greater …

Endogenous estrogens are important regulators of cardiovascular homeostasis in
premenopausal women and delay the development of hypertension and coronary artery …

Premenopausal females have a lower incidence of cardiovascular disease than their male
counterparts, but the mechanism is unclear. Estrogen has been thought to signal through …

Estrogens promote beneficial effects in the cardiovascular system mainly through the
estrogen receptor (ER) α and ERβ, which act as ligand-gated transcription factors. Recently …