Synthesis and biological evaluation of novel tricyclic oxazine and oxazepine fused quinazolines. Part 2: Gefitinib analogs
M Sun, J Zhao, X Chen, Z Zong, J Han, Y Du… - Bioorganic & Medicinal …, 2016 - Elsevier
Two series of novel tricyclic oxazine and oxazepine fused quinazolines have been designed
and synthesized. The in vitro antitumor effect of the title compounds was screened on N87 …
and synthesized. The in vitro antitumor effect of the title compounds was screened on N87 …
Synthesis and biological evaluation of novel tricyclic oxazine and oxazepine fused quinazolines. Part 1: erlotinib analogs
X Chen, Y Du, H Sun, F Wang, L Kong… - Bioorganic & medicinal …, 2014 - Elsevier
Two series of novel tricyclic oxazine and oxazepine fused quinazolines have been designed
and synthesized. The in vitro antitumor effect of the title compounds was screened on N87 …
and synthesized. The in vitro antitumor effect of the title compounds was screened on N87 …
Design, synthesis, anticancer activity and docking studies of novel quinazoline-based thiazole derivatives as EGFR kinase inhibitors
The in vitro anticancer efficacy of a new series of quinazoline-based thiazole derivatives was
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
Novel amide analogues of quinazoline carboxylate display selective antiproliferative activity and potent EGFR inhibition
A Malhotra, R Bansal, CE Halim, CT Yap… - Medicinal Chemistry …, 2020 - Springer
In the present study, a novel series of quinazoline derivatives is developed for cancer
therapy. All the synthesised analogues were evaluated against a panel of 60 human cancer …
therapy. All the synthesised analogues were evaluated against a panel of 60 human cancer …
Synthesis and biological evaluation of quinazoline derivatives as potential anticancer agents (II)
J Yong, C Lu, X Wu - Anti-Cancer Agents in Medicinal …, 2015 - ingentaconnect.com
Under the guidance of our previous work, we synthesized 21 new structures of quinazolines
(3a~ 3u) and evaluated their in vitro anticancer activity against A549, HCT116 and MCF-7 …
(3a~ 3u) and evaluated their in vitro anticancer activity against A549, HCT116 and MCF-7 …
Novel oxazolo [4, 5-g] quinazolin-2 (1H)-ones: dual inhibitors of EGFR and Src protein tyrosine kinases
J Lin, W Shen, J Xue, J Sun, X Zhang… - European journal of …, 2012 - Elsevier
Quinazoline-containing derivatives are an important class of synthetic products and
represent an attractive scaffold for EGFR inhibitors. A series of oxazolo [4, 5-g] quinazolin-2 …
represent an attractive scaffold for EGFR inhibitors. A series of oxazolo [4, 5-g] quinazolin-2 …
Synthesis of novel triazoloquinoxaline‐pyrazole hybrids as antiproliferatives, EGFR inhibitors, and apoptosis inducers
HS El Saeed, AH Bayoumi, MT Sarg… - Journal of Heterocyclic …, 2020 - Wiley Online Library
Novel triazoloquinoxaline‐pyrazole hybrids have been developed and synthesized. All
derivatives' anticancer activity has been evaluated using Sulforhodamine‐B (SRB) assay for …
derivatives' anticancer activity has been evaluated using Sulforhodamine‐B (SRB) assay for …
Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines
MD Gaul, Y Guo, K Affleck, GS Cockerill… - Bioorganic & medicinal …, 2003 - Elsevier
We have identified a novel class of 6-thiazolylquinazolines as potent and selective inhibitors
of both ErbB-2 and EGFR tyrosine kinase activity, with IC50 values in the nanomolar range …
of both ErbB-2 and EGFR tyrosine kinase activity, with IC50 values in the nanomolar range …
Design and synthesis of a novel class EGFR/HER2 dual inhibitors containing tricyclic oxazine fused quinazolines scaffold
M Sun, J Jia, H Sun, F Wang - Bioorganic & Medicinal Chemistry Letters, 2020 - Elsevier
Two series of novel tricyclic oxazine and oxazepine fused quinazolines have been
designed, synthesized and evaluated for their inhibitory activity against EGFR and HER2 …
designed, synthesized and evaluated for their inhibitory activity against EGFR and HER2 …
Synthesis and antitumor evaluation of 2, 4-substituted quinazoline derivatives containing benzimidazole
N Li, J Xin, Y Meng, E Li, Q Ma, C Bao… - Chinese Journal of …, 2018 - sioc-journal.cn
In order to find more efficient and economical antitumor drugs, a series of novel 2, 4-
substituted quinazoline derivatives containing benzimidazole were designed, synthesized …
substituted quinazoline derivatives containing benzimidazole were designed, synthesized …