Although the specific functions of sleep are not known, an increasing body of literature has
suggested that sleep is important for the proper functioning of host defense systems. Sleep …

Despite considerable progress in our understanding of the phenomenology of sleep and
wakefulness, their regulation and peculiar functions are poorly understood. Recent animal …

Fatigue and excess sleep, combined with fever, are presenting symptoms in nearly all
infectious diseases and chronic inflammatory disorders. Fever, because it is easily …

The discovery of reciprocal connections between the central nervous system, sleep and the
immune system has shown that sleep enhances immune defences and that afferent signals …

For millennia individuals have known that sleep is altered during sickness, and indeed many
follow the advice to get sleep as an aid for recuperation from disease states. Hippocrates …

Poor sleep is an important risk factor for the development and progression of disease;
however, the biological mechanisms are not well elucidated. The immune system has …

Sleep is considered an important modulator of the immune response. Thus, a lack of sleep
can weaken immunity, increasing organism susceptibility to infection. For instance, shorter …

Sleep is a fundamental physiologic process with unknown functions. It is divided into 2
distinct states: non–rapid-eye-movement sleep and rapid-eye-movement sleep. After acute …

Thermoregulation and sleep are tightly coordinated, with evidence that impairments in
thermoregulation as well as increases in ambient temperature increase the risk of sleep …

It is a common belief that we are more susceptible to infections when deprived of sleep.
Consistent with this, there is increasing evidence that sleep deprivation has detrimental …