Gender-related differences in pharmacokinetics have frequently been considered as
potentially important determinants for the clinical effectiveness of drug therapy. The …

Significant differences that exist between the sexes affect the prevalence, incidence and
severity of a broad range of diseases and conditions. Men and women also differ in their …

There are a number of examples of sex differences in drug pharmacokinetics and
pharmacodynamics. Recent advances in the characterisation of specific isozymes involved …

Pharmacological response depends on multiple factors and one of them is sex–gender.
Data on the specific effects of sex–gender on pharmacokinetics, as well as the safety and …

The role of gender on the disposition of drugs metabolized by cytochrome P4503A (CYP3A)
remains controversial. Some sources suggest that CYP3A activity in women exceeds that in …

Biologic differences exist between men and women that can result in differences in
responses to drugs. Both pharmacokinetic and pharmacodynamic differences between the …

In this review I have attempted to summarize gender differences in pharmacokinetics
involving the cytochrome P450 (CYP) isozymes of young and mature adults, excluding the …

Several years ago regulatory authorities requested to include women in all phases of clinical
drug development in order to thoroughly investigate potential gender differences in the …

The Food and Drug Administration (FDA) reviewed 300 new drug applications between
1995 and 2000. Of the 163 that included a sex analysis, 11 drugs showed a> 40% difference …

Research on the specific effects of sex and gender on pharmacokinetics and
pharmacodynamics, as well as safety profile tolerability and drug efficacy, of medications …