Research on the specific effects of sex and gender on pharmacokinetics and
pharmacodynamics, as well as safety profile tolerability and drug efficacy, of medications …

Physiologic differences between men and women affect drug activity, including
pharmacokinetics and pharmacodynamics. Pharmacokinetics in women is affected by lower …

While there is considerable evidence about sex-related differences between men and
women in drug metabolism, efficacy and safety of frequently prescribed drugs such as …

Background Women experience adverse drug reactions, ADRs, nearly twice as often as
men, yet the role of sex as a biological factor in the generation of ADRs is poorly understood …

Abstract Professor Henry Higgins in My Fair Lady said,'Why can'ta woman be more like a
man?'Perhaps unintended, such narration extends to the reality of current drug …

In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences
of biologic sex produces different in vivo environments for male and female cells. We dissect …

The International Conference on Harmonization has put forth a tripartite guideline
addressing mechanisms by which regulatory agencies might be able to accept foreign …

Physiological, hormonal, and genetic differences between males and females affect the
prevalence, incidence, and severity of diseases and responses to therapy. Understanding …

Historically, women, the elderly, and minorities were underrepresented in clinical drug trials.
Information on possible gender-related differences in the pharmacokinetics of drugs is often …

Gender differences in pharmacokinetics and pharmacodynamics have long been
recognized in animals. In humans, however, little attention has been paid to this field despite …