Statin use is associated with lower disease severity in COVID-19 infection

WYT Tan, BE Young, DC Lye, DEK Chew, R Dalan - Scientific reports, 2020 - nature.com
We aim to study the association of hyperlipidemia and statin use with COVID-19 severity. We
analysed a retrospective cohort of 717 patients admitted to a tertiary centre in Singapore for …

Statins use and COVID-19 outcomes in hospitalized patients

SK Ayeh, EJ Abbey, BAA Khalifa, RD Nudotor… - PLoS …, 2021 - journals.plos.org
Background There is an urgent need for novel therapeutic strategies for reversing COVID-19-
related lung inflammation. Recent evidence has demonstrated that the cholesterol-lowering …

Association between statin use and outcomes in patients with coronavirus disease 2019 (COVID-19): a nationwide cohort study

JH Butt, TA Gerds, M Schou, K Kragholm, M Phelps… - BMJ open, 2020 - bmjopen.bmj.com
Objective To investigate the association between recent statin exposure and risk of severe
COVID-19 infection and all-cause mortality in patients with COVID-19 in Denmark. Design …

The effect of statins on clinical outcome among hospitalized patients with COVID-19: a multi-centric cohort study

S Umakanthan, S Senthil, S John… - Frontiers in …, 2022 - frontiersin.org
The coronavirus disease-2019 (COVID-19) is caused by SARS-CoV-2, leading to acute
respiratory distress syndrome (ARDS), thrombotic complications, and myocardial injury …

Statins in patients with COVID-19: a retrospective cohort study in Iranian COVID-19 patients

P Peymani, T Dehesh, F Aligolighasemabadi… - Translational medicine …, 2021 - Springer
Background The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has profoundly affected the …

Impact of prior statin use on clinical outcomes in COVID-19 patients: data from tertiary referral hospitals during COVID-19 pandemic in Italy

G Mitacchione, M Schiavone, A Curnis, M Arca… - Journal of clinical …, 2021 - Elsevier
Background Epidemiological evidence suggests that anti-inflammatory and
immunomodulatory properties of statins may reduce the risk of infections and infection …

Statin use in COVID-19 hospitalized patients and outcomes: a retrospective study

H Kouhpeikar, H Khosaravizade Tabasi… - Frontiers in …, 2022 - frontiersin.org
Background Coronavirus disease 2019 (COVID-19) might affect everyone, but people with
comorbidities such as hypertension and cardiovascular disease (CVD) may often have more …

Statin use and clinical outcomes in patients with COVID-19: An updated systematic review and meta-analysis

R Pal, M Banerjee, U Yadav… - Postgraduate medical …, 2022 - academic.oup.com
Purpose Observations studies have shown that prior use of statins is associated with a
reduced risk of adverse clinical outcomes in patients with COVID-19. However, the available …

The protective association between statins use and adverse outcomes among COVID-19 patients: a systematic review and meta-analysis

R Chow, J Im, N Chiu, L Chiu, R Aggarwal, J Lee… - PLoS …, 2021 - journals.plos.org
Introduction Statins may reduce a cytokine storm, which has been hypothesized as a
possible mechanism of severe COVID-19 pneumonia. The aim of this study was to conduct a …

The use of statins was associated with reduced COVID-19 mortality: a systematic review and meta-analysis

KS Wu, PC Lin, YS Chen, TC Pan, PL Tang - Annals of medicine, 2021 - Taylor & Francis
Background Statins are widely used to treat people with metabolic and cardiovascular
disorders. The effect of statins on coronavirus disease 2019 (COVID-19) is unclear. To …