The interaction of the T-cell receptor (TCR) with peptide antigen plus major
histocompatibility complex (MHC) protein requires both alpha and beta chains of the TCR …

Several studies have suggested that there is a direct interaction between the T cell receptor
(TCR) and the major histocompatibility complex (MHC) molecule during T cell recognition of …

We have used multiple-amino acid replacement mutagenesis to examine the roles of the
TCR homologues of Ig complementarity-determining regions (CDR) and framework …

Bacterial toxin superantigens bind to MHC class II molecules and activate a large proportion
of T cells through a direct interaction with the T cell receptor (TCR). The toxin: TCR …

The genes for the alpha and beta chains of a murine T-cell receptor were truncated just prior
to the portions encoding the transmembrane regions and introduced into baculovirus by …

A defining characteristic of superantigens is their ability to stimulate T cells based
predominantly on the type of variable segment of the T cell receptor (TCR) beta chain (V …

THE αβ T-cell antigen receptor (TCR) recognizes antigenic peptides in the context of self
major histocompatibility complex (MHC) molecules1–4. The specificity of recognition of MHC …

The T-cell antigen receptor (TCR) is a heterodimeric structure composed of highly variable a
and^ chains. Foreign antigens are presented to the TCR in the form of short peptides bound …

The three-dimensional structure of an unglycosylated T cell antigen receptor (TCR) beta
chain has recently been determined to 1.7 A resolution. To investigate whether this soluble …

Superantigen bound to major histocompatibility complex (MHC) products have been shown
to stimulate T cells in a V beta-specific manner. Mouse T cells bearing V beta 8.1 usually …